Jonathan L. Halperin
Encyclopedia
Jonathan L. Halperin, M.D., is an American
cardiologist
and the author of Bypass (ISBN 0895865092), among the most comprehensive works on the subject of coronary artery bypass surgery. In addition, he is the Robert and Harriet Heilbrunn Professor of Medicine at The Mount Sinai School of Medicine
as well as Director of Clinical Cardiology in the Zena and Michael A. Wierner Cardiovascular Institute at The Mount Sinai Medical Center
, both in New York City
. Halperin was the principal cardiologist responsible for both the design and execution of the multi-center Stroke Prevention in Atrial Fibrillation (SPAF) clinical trials, funded by the National Institutes of Health
, which helped develop antithrombotic
strategies to prevent stroke
, and he subsequently directed the SPORTIF clinical trials, which evaluated the first oral direct thrombin inhibitor
for prevention of stroke in patients with atrial fibrillation
.
Halperin is the author of 3 books, 80 original peer reviewed reports, 38 chapters, 24 guidelines and position statements, 51 invited articles and 58 abstracts. He is listed among New York Magazine
’s Best Doctors of 2009.
, Massachusetts
. He earned his A.B. from Columbia University
in 1971 and his M.D. from Boston University
in 1975. He completed an internship in medicine (in 1976) and a residency in internal medicine (in 1977), both at University Hospital, Boston. He was a clinical and research fellow in peripheral vascular disease at the Evans Memorial Foundation for Clinical Research in Boston (1977–1978) and a fellow in cardiology at Boston City Hospital
(1978–1980). He served academic appointments at Boston City Hospital, St. Elizabeth's Hospital
in Brighton, Massachusetts, Boston University School of Medicine
and the American Heart Association
. In 1980, Halperin was appointed to The Mount Sinai School of Medicine as an Assistant Professor of Medicine. In 1993, he was named the Robert and Harriet Heilbrunn Professor of Medicine.
Halperin is a fellow the American College of Cardiology
, the American Heart Association
, and the Councils on Circulation, Stroke and Cardiology of the American Heart Association. He is past president of the Society for Vascular Medicine.
Current federal appointments include the U.S Food and Drug Administration’s Cardiovascular and Renal Advisory Committee, and the Data Safety Monitoring Board
for the Clinical Trial of Aspirin
and Simvastatin
in Pulmonary Arterial Hypertension for the National Institutes of Health.
Clinical investigation topics include congestive heart failure, Raynaud's disease
and mitral valve disease
.
United States
The United States of America is a federal constitutional republic comprising fifty states and a federal district...
cardiologist
Cardiology
Cardiology is a medical specialty dealing with disorders of the heart . The field includes diagnosis and treatment of congenital heart defects, coronary artery disease, heart failure, valvular heart disease and electrophysiology...
and the author of Bypass (ISBN 0895865092), among the most comprehensive works on the subject of coronary artery bypass surgery. In addition, he is the Robert and Harriet Heilbrunn Professor of Medicine at The Mount Sinai School of Medicine
Mount Sinai School of Medicine
Mount Sinai School of Medicine is an American medical school in the borough of Manhattan in New York City, currently ranked among the top 20 medical schools in the United States. It was chartered by Mount Sinai Hospital in 1963....
as well as Director of Clinical Cardiology in the Zena and Michael A. Wierner Cardiovascular Institute at The Mount Sinai Medical Center
Mount Sinai Hospital, New York
Mount Sinai Hospital, founded in 1852, is one of the oldest and largest teaching hospitals in the United States. In 2011-2012, Mount Sinai Hospital was ranked as one of America's best hospitals by U.S...
, both in New York City
New York City
New York is the most populous city in the United States and the center of the New York Metropolitan Area, one of the most populous metropolitan areas in the world. New York exerts a significant impact upon global commerce, finance, media, art, fashion, research, technology, education, and...
. Halperin was the principal cardiologist responsible for both the design and execution of the multi-center Stroke Prevention in Atrial Fibrillation (SPAF) clinical trials, funded by the National Institutes of Health
National Institutes of Health
The National Institutes of Health are an agency of the United States Department of Health and Human Services and are the primary agency of the United States government responsible for biomedical and health-related research. Its science and engineering counterpart is the National Science Foundation...
, which helped develop antithrombotic
Antithrombotic
A antithrombotic is a drug which reduces thrombus formation.Different antithrombotics affect different processes:* Antiplatelet drugs limit the migration or aggregation of platelets.* Anticoagulants limit the ability of the blood to clot....
strategies to prevent stroke
Stroke
A stroke, previously known medically as a cerebrovascular accident , is the rapidly developing loss of brain function due to disturbance in the blood supply to the brain. This can be due to ischemia caused by blockage , or a hemorrhage...
, and he subsequently directed the SPORTIF clinical trials, which evaluated the first oral direct thrombin inhibitor
Direct thrombin inhibitor
Direct thrombin inhibitors are a class of medication that act as anticoagulants by directly inhibiting the enzyme thrombin. Some are in clinical use, while others are undergoing clinical development...
for prevention of stroke in patients with atrial fibrillation
Atrial fibrillation
Atrial fibrillation is the most common cardiac arrhythmia . It is a common cause of irregular heart beat, identified clinically by taking a pulse. Chaotic electrical activity in the two upper chambers of the heart result in the muscle fibrillating , instead of achieving coordinated contraction...
.
Halperin is the author of 3 books, 80 original peer reviewed reports, 38 chapters, 24 guidelines and position statements, 51 invited articles and 58 abstracts. He is listed among New York Magazine
New York (magazine)
New York is a weekly magazine principally concerned with the life, culture, politics, and style of New York City. Founded by Milton Glaser and Clay Felker in 1968 as a competitor to The New Yorker, it was brasher and less polite than that magazine, and established itself as a cradle of New...
’s Best Doctors of 2009.
Biography
Halperin was born in 1949 in BostonBoston
Boston is the capital of and largest city in Massachusetts, and is one of the oldest cities in the United States. The largest city in New England, Boston is regarded as the unofficial "Capital of New England" for its economic and cultural impact on the entire New England region. The city proper had...
, Massachusetts
Massachusetts
The Commonwealth of Massachusetts is a state in the New England region of the northeastern United States of America. It is bordered by Rhode Island and Connecticut to the south, New York to the west, and Vermont and New Hampshire to the north; at its east lies the Atlantic Ocean. As of the 2010...
. He earned his A.B. from Columbia University
Columbia University
Columbia University in the City of New York is a private, Ivy League university in Manhattan, New York City. Columbia is the oldest institution of higher learning in the state of New York, the fifth oldest in the United States, and one of the country's nine Colonial Colleges founded before the...
in 1971 and his M.D. from Boston University
Boston University
Boston University is a private research university located in Boston, Massachusetts. With more than 4,000 faculty members and more than 31,000 students, Boston University is one of the largest private universities in the United States and one of Boston's largest employers...
in 1975. He completed an internship in medicine (in 1976) and a residency in internal medicine (in 1977), both at University Hospital, Boston. He was a clinical and research fellow in peripheral vascular disease at the Evans Memorial Foundation for Clinical Research in Boston (1977–1978) and a fellow in cardiology at Boston City Hospital
Boston Medical Center
Boston Medical Center is a non-profit 639 licensed-bed medical center in Boston, Massachusetts. It was created by the formal merger of Boston City Hospital which was the first municipal hospital in the United States and Boston University Medical Center Hospital in July 1996 which was sponsored...
(1978–1980). He served academic appointments at Boston City Hospital, St. Elizabeth's Hospital
St. Elizabeth's Medical Center (Boston)
St. Elizabeth's Medical Center is a large medical facility and teaching hospital in the Brighton neighborhood of Boston, Massachusetts....
in Brighton, Massachusetts, Boston University School of Medicine
Boston University School of Medicine
Boston University School of Medicine is one of the graduate schools of Boston University. Founded in 1848, the medical school holds the unique distinction as the first institution in the world to formally educate female physicians. Originally known as the New England Female Medical College, it was...
and the American Heart Association
American Heart Association
The American Heart Association is a non-profit organization in the United States that fosters appropriate cardiac care in an effort to reduce disability and deaths caused by cardiovascular disease and stroke. It is headquartered in Dallas, Texas...
. In 1980, Halperin was appointed to The Mount Sinai School of Medicine as an Assistant Professor of Medicine. In 1993, he was named the Robert and Harriet Heilbrunn Professor of Medicine.
Halperin is a fellow the American College of Cardiology
American College of Cardiology
The American College of Cardiology is a nonprofit medical association established in 1949 to advocate for quality cardiovascular care through education, research promotion, development and application of standards and guidelines, and to influence health care policy...
, the American Heart Association
American Heart Association
The American Heart Association is a non-profit organization in the United States that fosters appropriate cardiac care in an effort to reduce disability and deaths caused by cardiovascular disease and stroke. It is headquartered in Dallas, Texas...
, and the Councils on Circulation, Stroke and Cardiology of the American Heart Association. He is past president of the Society for Vascular Medicine.
Current federal appointments include the U.S Food and Drug Administration’s Cardiovascular and Renal Advisory Committee, and the Data Safety Monitoring Board
Data Monitoring Committees
A Data Monitoring Committee — sometimes called a Data and Safety Monitoring Board — is an independent group of experts who monitor patient safety and treatment efficacy data while a clinical trial is ongoing.- Need for a DMC :...
for the Clinical Trial of Aspirin
Aspirin
Aspirin , also known as acetylsalicylic acid , is a salicylate drug, often used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. It was discovered by Arthur Eichengrun, a chemist with the German company Bayer...
and Simvastatin
Simvastatin
Simvastatin is a hypolipidemic drug used to control elevated cholesterol, or hypercholesterolemia. Simvastatin is a member of the statin class of pharmaceuticals, is a synthetic derivate of a fermentation product of Aspergillus terreus.-Medical uses:The primary uses of simvastatin is for the...
in Pulmonary Arterial Hypertension for the National Institutes of Health.
Clinical investigation topics include congestive heart failure, Raynaud's disease
Raynaud's phenomenon
In medicine, Raynaud's phenomenon is a vasospastic disorder causing discoloration of the fingers, toes, and occasionally other areas. This condition can also cause nails to become brittle with longitudinal ridges. Named for French physician Maurice Raynaud , the phenomenon is believed to be the...
and mitral valve disease
Mitral regurgitation
Mitral regurgitation , mitral insufficiency or mitral incompetence is a disorder of the heart in which the mitral valve does not close properly when the heart pumps out blood. It is the abnormal leaking of blood from the left ventricle, through the mitral valve, and into the left atrium, when...
.
Honors and awards
Extramural honors and awards include:- Master of the Society for Vascular Medicine, 2009
- The Heart of New York Award, 2005
- The Heart of New York Presidential Salute, 2002
- Howard B. Sprague Research Fellowship Award, 1979
Books
- Halperin JL, Levine R: BYPASS: A Cardiologist Reveals What Every Patient Needs To Know. New York: Times Books – Random House, 1985 ISBN 0812911571; Phoenix: The Body Press – HP Books, 1987 ISBN 0895865092
- Gross PA, Halperin JL, Lipkin M, Marks JH, Rivlin RS, Wise TN, Grzelka C: Managing Your Health: Strategies for Lifelong Good Health. Yonkers, NY: Consumer Reports Books, 1991. ISBN 0890434387
- Connolly SJ, Gore JL, Halperin JL. Aligning Clinical Practice with Evidence for Prevention of Thromboembolism in Atrial Fibrillation. Institute for Continuing Healthcare Education, 2002.
External links
- Mount Sinai Hospital homepage
- Mount Sinai School of Medicine homepage
- TheHeart.org Kowey PR, Halperin JL, Yusuf S. Trial Design for Anticoagulation in Atrial Fibrillation Patients. American College of Cardiology Annual Scientific Sessions, March 30, 2009
- New York Daily News A Mount Sinai cardiologist makes sure your heart's in the right place. By Katie Charles, February 13, 2008