KIAA1303
Encyclopedia
Regulatory-associated protein of mTOR (raptor; KIAA1303) is an adapter protein
that is encoded in humans by the RPTOR gene
. Two mRNAs from the gene have been identified that encode proteins of 1335 (isoform 1) and 1177 (isoform 2) amino acids long.
with mammalian target of rapamycin
(mTOR), RICTOR
, FKBP1A
, EIF4EBP1
, P70-S6 Kinase 1
and RHEB
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that is encoded in humans by the RPTOR gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
. Two mRNAs from the gene have been identified that encode proteins of 1335 (isoform 1) and 1177 (isoform 2) amino acids long.
Interactions
Raptor has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with mammalian target of rapamycin
Mammalian target of rapamycin
The mammalian target of rapamycin also known as mechanistic target of rapamycin or FK506 binding protein 12-rapamycin associated protein 1 is a protein which in humans is encoded by the FRAP1 gene...
(mTOR), RICTOR
RICTOR
Rapamycin-insensitive companion of mTOR is a protein that in humans is encoded by the RICTOR gene.-Interactions:RICTOR has been shown to interact with Mammalian target of rapamycin and KIAA1303.-Further reading:...
, FKBP1A
FKBP1A
Peptidyl-prolyl cis-trans isomerase FKBP1A is an enzyme that in humans is encoded by the FKBP1A gene.-Interactions:FKBP1A has been shown to interact with RYR1, Mammalian target of rapamycin, TGF beta receptor 1, GLMN, ITPR1 and KIAA1303....
, EIF4EBP1
EIF4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1 is a protein that in humans is encoded by the EIF4EBP1 gene.-Interactions:EIF4EBP1 has been shown to interact with Mammalian target of rapamycin, EIF4E and KIAA1303.-Further reading:...
, P70-S6 Kinase 1
P70-S6 Kinase 1
Ribosomal protein S6 kinase beta-1 is an enzyme that in humans is encoded by the RPS6KB1 gene.-Interactions:P70-S6 Kinase 1 has been shown to interact with CSNK2B, EIF3B, COASY, KIAA1303, POLDIP3, Mammalian target of rapamycin, PPP2R2A, RBX1 and Ubiquitin C.-References:...
and RHEB
RHEB
GTP-binding protein Rheb also known as Ras homolog enriched in brain is a protein that in humans is encoded by the RHEB gene.- Function :Rheb is a recently discovered member of the Ras superfamily that may be involved in neural plasticity...
.