Karen Ashe
Encyclopedia
Karen K. Hsiao Ashe is a professor
at the Department of Neurology
and Neuroscience
at the University of Minnesota
, where she holds the
Edmund Wallace and Anne Marie Tulloch Chairs in Neurology and Neuroscience. She is Director of the Neurobiology of Alzheimer’s Disease Research Laboratory at the University, and her specific research interest is memory loss
resulting from Alzheimer's disease
, and preventive care for the disease. Her research has included the development of a line of genetically engineered mice
that develop symptoms similar to Alzheimer’s, the discovery of abnormal proteins that disrupt brain activity in the early stages of the disease, and the possibility of reversing memory loss due to the disease.
Ashe graduated from St. Paul Academy and Summit School
before graduating from Harvard University
. She went on to earn an MD
in Medicine from Harvard, and subsequently completed her PhD
at MIT. She joined the University of Minnesota in 1992. She has also studied at the University of California
.
Professor
A professor is a scholarly teacher; the precise meaning of the term varies by country. Literally, professor derives from Latin as a "person who professes" being usually an expert in arts or sciences; a teacher of high rank...
at the Department of Neurology
Neurology
Neurology is a medical specialty dealing with disorders of the nervous system. Specifically, it deals with the diagnosis and treatment of all categories of disease involving the central, peripheral, and autonomic nervous systems, including their coverings, blood vessels, and all effector tissue,...
and Neuroscience
Neuroscience
Neuroscience is the scientific study of the nervous system. Traditionally, neuroscience has been seen as a branch of biology. However, it is currently an interdisciplinary science that collaborates with other fields such as chemistry, computer science, engineering, linguistics, mathematics,...
at the University of Minnesota
University of Minnesota
The University of Minnesota, Twin Cities is a public research university located in Minneapolis and St. Paul, Minnesota, United States. It is the oldest and largest part of the University of Minnesota system and has the fourth-largest main campus student body in the United States, with 52,557...
, where she holds the
Edmund Wallace and Anne Marie Tulloch Chairs in Neurology and Neuroscience. She is Director of the Neurobiology of Alzheimer’s Disease Research Laboratory at the University, and her specific research interest is memory loss
Memory loss
Memory loss can be partial or total and it is normal when it comes with aging. Sudden memory loss is usually a result of brain trauma and it may be permanent or temporary. When it is caused by medical conditions such as Alzheimers, the memory loss is gradual and tends to be permanent.Brain trauma...
resulting from Alzheimer's disease
Alzheimer's disease
Alzheimer's disease also known in medical literature as Alzheimer disease is the most common form of dementia. There is no cure for the disease, which worsens as it progresses, and eventually leads to death...
, and preventive care for the disease. Her research has included the development of a line of genetically engineered mice
Mouse
A mouse is a small mammal belonging to the order of rodents. The best known mouse species is the common house mouse . It is also a popular pet. In some places, certain kinds of field mice are also common. This rodent is eaten by large birds such as hawks and eagles...
that develop symptoms similar to Alzheimer’s, the discovery of abnormal proteins that disrupt brain activity in the early stages of the disease, and the possibility of reversing memory loss due to the disease.
Ashe graduated from St. Paul Academy and Summit School
St. Paul Academy and Summit School
St. Paul Academy and Summit School is a college preparatory independent day school in St. Paul, Minnesota, for students in grades K–12....
before graduating from Harvard University
Harvard University
Harvard University is a private Ivy League university located in Cambridge, Massachusetts, United States, established in 1636 by the Massachusetts legislature. Harvard is the oldest institution of higher learning in the United States and the first corporation chartered in the country...
. She went on to earn an MD
Doctor of Medicine
Doctor of Medicine is a doctoral degree for physicians. The degree is granted by medical schools...
in Medicine from Harvard, and subsequently completed her PhD
PHD
PHD may refer to:*Ph.D., a doctorate of philosophy*Ph.D. , a 1980s British group*PHD finger, a protein sequence*PHD Mountain Software, an outdoor clothing and equipment company*PhD Docbook renderer, an XML renderer...
at MIT. She joined the University of Minnesota in 1992. She has also studied at the University of California
University of California
The University of California is a public university system in the U.S. state of California. Under the California Master Plan for Higher Education, the University of California is a part of the state's three-tier public higher education system, which also includes the California State University...
.
Selected publications
- "A specific amyloid-beta protein assembly in the brain impairs memory " by Sylvain Lesné , Ming Teng Koh , Linda Kotilinek , Rakez Kayed , Charles G. Glabe , Austin Yang , Michela Gallagher and Karen H. Ashe NatureNatureNature, in the broadest sense, is equivalent to the natural world, physical world, or material world. "Nature" refers to the phenomena of the physical world, and also to life in general...
Volume: 440 Issue: 7082 Pages: 352-357 , Mar 16 2006. - "Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease " by G. P. Lim, F. Yang, T. Chu, P. Chen, W. Beech, B. Teter, T. Tran, O. Ubeda, K. Hsiao Ashe , S. A. Frautschy, and G. M. Cole Journal of NeuroscienceJournal of NeuroscienceThe Journal of Neuroscience is a weekly scientific journal published by the Society for Neuroscience. The journal publishes peer-reviewed empirical research articles in the field of neuroscience...
Volume: 20 Issue: 15 Pages: 5709-5714 : Aug 1 2000. - "Natural oligomers of the amyloid-protein specifically disrupt cognitive function" by J. Cleary, D. M. Walsh, J.J. Hofmeister, G.M. Shankar, M.A. Kuskowski, D.J. Selkoe, K.H. Ashe Nature NeuroscienceNature NeuroscienceNature Neuroscience is a monthly scientific journal published by Nature Publishing Group. Its focus is original research papers relating specifically to neuroscience and was established in May 1998. According to the Journal Citation Reports, Nature Neuroscience has a 2009 impact factor of 14.345,...
Volume: 8 Issue: 1 Pages: 79-84 Published: Jan 2005.