Kentucky Route 21 is a 14.196 miles (22.8 km) west-east highway in Madison County

Madison County, Kentucky

Madison County is a county located in the U.S. state of Kentucky. As of 2008, the population was 82,192. Its county seat is Richmond. The county is named for Virginia statesman James Madison, who later became the fourth President of the United States. This is also where famous pioneer Daniel...

, running from the Garrard County

Garrard County, Kentucky

Garrard County is a county located in the U.S. state of Kentucky. It is pronounced 'Gair-ad' with the third "r" silent. It was formed in 1797 and was named for James Garrard, Governor of Kentucky from 1796 to 1804. Its county seat is Lancaster. The population was 16,912 in the 2010 Census...

 line near Paint Lick

Paint Lick, Kentucky

Paint Lick is an unincorporated community in Garrard County, Kentucky, United States. It lies along Routes 21 and 52 east of the city of Lancaster, the county seat of Garrard County. Its elevation is 820 feet . Although it is unincorporated, it has a post office, with the ZIP code of 40461...

 to Bighill

Bighill, Kentucky

Bighill is an unincorporated community in Madison County, Kentucky, United States. It lies east of Berea on Kentucky Route 21. The community is part of the Richmond–Berea Micropolitan Statistical Area....

, east of Berea

Berea, Kentucky

-Demographics:As of the census of 2000, there were 9,851 people, 3,693 households, and 2,426 families residing in the city. The population density was 1,055.4 people per square mile . There were 4,115 housing units at an average density of 440.9 per square mile...

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It begins at KY 52 at the Garrard County

Garrard County, Kentucky

Garrard County is a county located in the U.S. state of Kentucky. It is pronounced 'Gair-ad' with the third "r" silent. It was formed in 1797 and was named for James Garrard, Governor of Kentucky from 1796 to 1804. Its county seat is Lancaster. The population was 16,912 in the 2010 Census...

 line at the Paint Lick Creek Bridge. The road passes through Wallaceton and traverses over Interstate 75 in Berea

Berea, Kentucky

-Demographics:As of the census of 2000, there were 9,851 people, 3,693 households, and 2,426 families residing in the city. The population density was 1,055.4 people per square mile . There were 4,115 housing units at an average density of 440.9 per square mile...

, where KY 21 shortly runs along with US 25

U.S. Route 25

U.S. Route 25 is a north–south United States highway that runs for from Brunswick, Georgia to the Ohio state line in Covington, Kentucky.-Georgia:...

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After US 25 breaks away and goes north toward the Blue Grass Army Depot

Blue Grass Army Depot

Blue Grass Army Depot is a U.S. Army conventional munitions and chemical weapon storage facility located in east central Kentucky, southeast of the cities of Lexington and Richmond, Kentucky, operated by the United States Army. The site, composed mainly of open fields and wooded areas, is used...

, KY 21 continues to the east and terminates at US 421

U.S. Route 421

U.S. Route 421 is a spur route of U.S. 21. It runs for from Michigan City, Indiana, at U.S. 20, to Fort Fisher in North Carolina. The highway goes through the cities of Indianapolis, Indiana, Lexington, Kentucky, Boone, North Carolina, Winston-Salem, North Carolina, Greensboro, North Carolina and...

 in Bighill

Bighill, Kentucky

Bighill is an unincorporated community in Madison County, Kentucky, United States. It lies east of Berea on Kentucky Route 21. The community is part of the Richmond–Berea Micropolitan Statistical Area....

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