LMO3
Encyclopedia
LIM domain only protein 3 is a transcription co-factor, which in humans is encoded by the LMO3 gene
. LMO3 interacts with the tumor suppressor p53
and regulates its function. LMO3 is considered to be an oncogene in Neuroblastoma
.
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
. LMO3 interacts with the tumor suppressor p53
P53
p53 , is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor that is involved in preventing cancer...
and regulates its function. LMO3 is considered to be an oncogene in Neuroblastoma
Neuroblastoma
Neuroblastoma is the most common extracranial solid cancer in childhood and the most common cancer in infancy, with an annual incidence of about 650 cases per year in the US , and 100 cases per year in the UK . Close to 50 percent of neuroblastoma cases occur in children younger than two years old...
.