LSD-Pip
Encyclopedia
LSD-Pip is a compound from the ergoline
family, related to LSD
but with the N,N-diethyl substitution replaced by a piperidine
group. It is more potent than the corresponding pyrrolidine and morpholine analogues (LPD-824
and LSM-775
respectively), but is still several times less potent than LSD as a 5-HT2A
agonist
. Early studies suggested this compound to be inactive as a hallucinogen in humans, though this does not seem to have been confirmed by any more recent work.
Ergoline
Ergoline is a chemical compound whose structural skeleton is contained in a diverse range of alkaloids including a few psychedelic drugs . Ergoline derivatives are used clinically for the purpose of vasoconstriction and in the treatment of migraines and Parkinson's disease...
family, related to LSD
LSD
Lysergic acid diethylamide, abbreviated LSD or LSD-25, also known as lysergide and colloquially as acid, is a semisynthetic psychedelic drug of the ergoline family, well known for its psychological effects which can include altered thinking processes, closed and open eye visuals, synaesthesia, an...
but with the N,N-diethyl substitution replaced by a piperidine
Piperidine
Piperidine is an organic compound with the molecular formula 5NH. This heterocyclic amine consists of a six-membered ring containing five methylene units and one nitrogen atom...
group. It is more potent than the corresponding pyrrolidine and morpholine analogues (LPD-824
LPD-824
N-Pyrrolidyllysergamide is a derivative of ergine. It is reported to have some mild, short lasting LSD-like effects at a dose of 800 micrograms. The use of LPD-824 has had a minor spike between 2006 and 2007 but after this time frame, virtually no reports of LPD-824 use have been documented....
and LSM-775
LSM-775
N-Morpholinyllysergamide is a derivative of ergine. It is reported to have some LSD-like effects at doses ranging from 75 to 700 micrograms. LSM-775 is said to produce dream like states similar to DXM. Its visual component is like that of LSD, but it is said to be less intense and not as...
respectively), but is still several times less potent than LSD as a 5-HT2A
5-HT2A receptor
The mammalian 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor . This is the main excitatory receptor subtype among the GPCRs for serotonin , although 5-HT2A may also have an inhibitory effect on certain areas such...
agonist
Agonist
An agonist is a chemical that binds to a receptor of a cell and triggers a response by that cell. Agonists often mimic the action of a naturally occurring substance...
. Early studies suggested this compound to be inactive as a hallucinogen in humans, though this does not seem to have been confirmed by any more recent work.