Langat virus is a virus of the genus Flavivirus

Flavivirus

Flavivirus is a genus of the family Flaviviridae. This genus includes the West Nile virus, dengue virus, tick-borne encephalitis virus, yellow fever virus, and several other viruses which may cause encephalitis....

. For the first time Langat virus was isolated in Malaysia and Thailand. This virus is close to Omsk hemorrhagic fever

Omsk hemorrhagic fever

Omsk Hemorrhagic Fever is a viral hemorrhagic fever caused by a Flavivirus.It is found in Siberia. It is named for an outbreak in Omsk.-Virology:...

 virus, Kyasanur forest disease

Kyasanur forest disease

Kyasanur forest disease is a tick-borne viral hemorrhagic fever endemic to South Asia. The disease is caused by a virus belonging to the family flaviviridae, which also includes yellow fever and dengue fever.-History:...

 virus, Alkhurma virus

Alkhurma virus

Alkhurma virus is a member of the Flaviviridae virus family .-Virology:The virus has a positive sense single stranded RNA genome and replicates in the cytoplasm of the infected host cell...

, Louping ill virus and the Tick-borne encephalitis virus

Tick-borne encephalitis virus

Tick-borne encephalitis virus is the virus associated with Tick-borne encephalitis.The responsible virus, Tick-Borne Encephalitis Virus , is a member of the genus Flavivirus...

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The Langat virus does not pose significant epidemiological threat in comparison with TBEV. There are no known cases of human diseases associated with LGTV, however antibodies to this virus have been detected in the sera of local people.

LGTV-based vaccine

In 1970s a live attenuate LGTV-based vaccine against tick-borne encephalitis was made. At the same time, another vaccine was tested, but the group vaccinated with the LGTV-based vaccine had the lowest level of developing infection decease. However, there were two big problems: the high level incidents of encephalitis (1:10 000) and not absolute protection from infection in endemic regions.