Lawrence Corey
Encyclopedia
Lawrence Corey Professor of Medicine and Laboratory Medicine at the University of Washington
and President of the Fred Hutchinson Cancer Research Center
, is an American physician-scientist and an internationally recognized expert in virology
, immunology
and vaccine
development.
His discoveries have been recognized as having advanced the understanding of the pathogenesis
and treatment of disease
s caused by virus
es, especially human immunodeficiency virus (HIV) and herpesviruses. These investigations included the development and testing of experimental vaccines for genital herpes and HIV, and developing new methods for diagnosing and monitoring therapies for viral infections.
In the early 1980s Corey worked with Nobel Prize-winning biochemist and pharmacologist Dr. Gertrude Elion to demonstrate that an antiviral that was selective and specific for a viral-specified enzyme could be safely and effectively administered to control a chronic viral infection (herpes simplex virus-2). These studies were directly responsible for the subsequent successful quest of the pharmaceutical and medical sciences communities to develop effective antiviral therapy for hepatitis B and HIV.
In 1987 Corey directed the AIDS Clinical Trials Group
, or ACTG, which conducted pivotal clinical trials confirming the use of the antiretroviral drug AZT
to reduce maternal-fetal transmission of HIV and the usefulness of highly active antiretroviral therapy (HAART). His research group was the first to identify an association between the virus that causes genital herpes (herpes simplex virus
) and HIV. Through the ACTG he also was the first to lead the integration of community members into clinical research activities.
In the mid-1990s Corey increasingly focused his work in the area of vaccine development, and in 1998 worked with the US National Institute of Allergy and Infectious Diseases
to develop a global clinical trials group to speed the development of HIV vaccines. In 2002, Corey became the major driver in conceiving of the Global HIV Vaccine Enterprise
. The Enterprise is one of the few scientific programs that is overseen by leaders of the major industrialized countries of the world.
In July 2008, Dr. Corey co-founded the biotechnology company Immune Design, to develop vaccines built on emerging understanding of the human immune system. The Company's additional founders include Dr. David Baltimore
, Nobel Laureate, former president of Caltech, and a leading immunologist; Dr. Steven Reed, founder of the Infectious Disease Research Institute
(IDRI), Dr. Lili Yang of Caltech, and Dr. Pin Wang of University of Southern California
. On July 30, 2010, Dr Corey was named the fourth president of the Fred Hutchinson Cancer Research Center
.
Corey received a B.A. (1967) and M.D. (1971) from the University of Michigan
, and received postgraduate training at the University of Michigan, University of Washington, and the U. S. Centers for Disease Control and Prevention
. In addition to his professorships at the University of Washington, Corey is currently principal investigator of the US HIV Vaccine Trials Network
and holder of the Lawrence Corey Endowed Chair in Medical Virology at the University of Washington. In 2008, he was elected to the Institute of Medicine
of the (US) National Academy of Sciences
. Dr. Corey is one of the most highly cited and funded investigators in the United States. He has authored 12 books and more than 600 scientific publications and is a member of numerous scientific committees and editorial boards, including the National Cancer Institute
Board of Scientific Counselors for Basic Sciences.
These studies led to pilot and large sale clinical trials of anti-HSV-2 therapy to reduce HIV acquisition and transmission Corey also published landmark papers showing the effectiveness of acyclovir in the treatment of genital herpes,
His current work includes the coordination of clinical trials sites and laboratories for Phase 1-3 trials of HIV vaccines. He continues to do research in defining persistent reservoirs of HIV infection, prevention of CMV and HHV-6 infections in immunocompromised hosts, epidemiological studies of the relationship between HSV and HIV infection, and, in general, development of new technologies for the diagnosis and treatment of viral infections.
. He is a fellow of the Infectious Diseases Society of America and a member of the American Epidemiological Society, American Society for Clinical Investigation
, and the Association of American Physicians
. In addition, he is the recipient of the Pan American Society’s Clinical Virology Award, the American Society for STD Research’s Parran Award, and the University of Michigan Medical School’s Distinguished Alumnus Award.
Lazaro CA, Chang M, Tang W, Campbell J, Sullivan DG, Gretch DR, Corey L, Coombs RW (2007) Hepatitis C virus replication in transfected and serum-infected cultured human fetal hepatocytes, The American Journal of Pathology, 170 (478-489).
Zerr DM, Meier AS, Selke SS, Frenkel LM, Huang ML, Wald A, Rhoads M, Nguy L, Bornemann R, Morrow RA, Corey L (2005) A population-based study of primary human herpesvirus 6 infection, The New England Journal of Medicine, 352, 768-776.
Corey L, Wald A, Patel R, Sacks SL, Tyring SK, Warren T, Douglas JM Jr, Paavonen J, Morrow RA, Beutner KR, Stratchounsky LS, Mertz G, Keene ON, Watson HA, Tait D, Vargas-Cortes M; Valacyclovir HSV Transmission Study Group (2004) Once daily valacyclovir to reduce the risk of transmission of genital herpes, The New England Journal of Medicine, 350, 11-20.
Klausner RD, Fauci AS, Corey L, Nabel GJ, Gayle H, Berkley S, Haynes BF, Baltimore D, Collins C, Douglas RG, Esparza J, Francis DP, Ganguly NK, Gerberding JL, Johnston MI, Kazatchkine MD, McMichael AJ, Makgoba MW, Pantaleo G, Piot P, Shao Y, Tramont E, Varmus H, Wasserheit JN (2003) The need for a global HIV vaccine enterprise, Science, 300, 2036-2039.
Wald A, Langenberg AGM, Link K, Izu A, Ashley R, Warren T, Tyring S, Douglas JM, Corey L (2001) Effect of condoms on reducing the transmission of herpes simplex virus type-2 from men to women, JAMA, 285, 3100-3106
Wald A, Zeh J, Selke S, Warren T, Ryncarz AJ, Ashley R, Krieger JN, Corey L (2000) Reactivation of genital herpes simplex virus type 2 infection in asymptomatic seropositive persons, The New England Journal of Medicine, 342(12), 844-50
McElrath M J, Corey L, Greenberg P D, Matthews T J, Montefiori D C, Rowen L, Hood L, Mullins JI (1996). Human immunodeficiency virus type 1 infection despite prior immunization with a recombinant envelope vaccine regimen, Proceedings of the National Academy of Sciences (USA), 93(9), 3972-7.
University of Washington
University of Washington is a public research university, founded in 1861 in Seattle, Washington, United States. The UW is the largest university in the Northwest and the oldest public university on the West Coast. The university has three campuses, with its largest campus in the University...
and President of the Fred Hutchinson Cancer Research Center
Fred Hutchinson Cancer Research Center
The Fred Hutchinson Cancer Research Center, is one of the world’s leading cancer research institutes...
, is an American physician-scientist and an internationally recognized expert in virology
Virology
Virology is the study of viruses and virus-like agents: their structure, classification and evolution, their ways to infect and exploit cells for virus reproduction, the diseases they cause, the techniques to isolate and culture them, and their use in research and therapy...
, immunology
Immunology
Immunology is a broad branch of biomedical science that covers the study of all aspects of the immune system in all organisms. It deals with the physiological functioning of the immune system in states of both health and diseases; malfunctions of the immune system in immunological disorders ; the...
and vaccine
Vaccine
A vaccine is a biological preparation that improves immunity to a particular disease. A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms of the microbe or its toxins...
development.
His discoveries have been recognized as having advanced the understanding of the pathogenesis
Pathogenesis
The pathogenesis of a disease is the mechanism by which the disease is caused. The term can also be used to describe the origin and development of the disease and whether it is acute, chronic or recurrent...
and treatment of disease
Disease
A disease is an abnormal condition affecting the body of an organism. It is often construed to be a medical condition associated with specific symptoms and signs. It may be caused by external factors, such as infectious disease, or it may be caused by internal dysfunctions, such as autoimmune...
s caused by virus
Virus
A virus is a small infectious agent that can replicate only inside the living cells of organisms. Viruses infect all types of organisms, from animals and plants to bacteria and archaea...
es, especially human immunodeficiency virus (HIV) and herpesviruses. These investigations included the development and testing of experimental vaccines for genital herpes and HIV, and developing new methods for diagnosing and monitoring therapies for viral infections.
In the early 1980s Corey worked with Nobel Prize-winning biochemist and pharmacologist Dr. Gertrude Elion to demonstrate that an antiviral that was selective and specific for a viral-specified enzyme could be safely and effectively administered to control a chronic viral infection (herpes simplex virus-2). These studies were directly responsible for the subsequent successful quest of the pharmaceutical and medical sciences communities to develop effective antiviral therapy for hepatitis B and HIV.
In 1987 Corey directed the AIDS Clinical Trials Group
AIDS Clinical Trials Group
The AIDS Clinical Trials Group is the largest HIV clinical trials organization in the world, playing a major role in setting standards of care for HIV infection and opportunistic diseases related to HIV and AIDS in the United States and the developed world. The ACTG is composed of, and directed...
, or ACTG, which conducted pivotal clinical trials confirming the use of the antiretroviral drug AZT
Zidovudine
Zidovudine or azidothymidine is a nucleoside analog reverse-transcriptase inhibitor , a type of antiretroviral drug used for the treatment of HIV/AIDS. It is an analog of thymidine....
to reduce maternal-fetal transmission of HIV and the usefulness of highly active antiretroviral therapy (HAART). His research group was the first to identify an association between the virus that causes genital herpes (herpes simplex virus
Herpes simplex virus
Herpes simplex virus 1 and 2 , also known as Human herpes virus 1 and 2 , are two members of the herpes virus family, Herpesviridae, that infect humans. Both HSV-1 and HSV-2 are ubiquitous and contagious...
) and HIV. Through the ACTG he also was the first to lead the integration of community members into clinical research activities.
In the mid-1990s Corey increasingly focused his work in the area of vaccine development, and in 1998 worked with the US National Institute of Allergy and Infectious Diseases
National Institute of Allergy and Infectious Diseases
The National Institute of Allergy and Infectious Diseases is one of the 27 institutes and centers that make up the National Institutes of Health , an agency of the United States Department of Health and Human Services...
to develop a global clinical trials group to speed the development of HIV vaccines. In 2002, Corey became the major driver in conceiving of the Global HIV Vaccine Enterprise
Global HIV Vaccine Enterprise
The Global HIV Vaccine Enterprise is an alliance of organizations formed to accelerate the search for an HIV vaccine. Initially proposed in Science magazine in 2003 and developed by scientists, health experts and policy makers, the concept of the Enterprise received support from the G8 the...
. The Enterprise is one of the few scientific programs that is overseen by leaders of the major industrialized countries of the world.
In July 2008, Dr. Corey co-founded the biotechnology company Immune Design, to develop vaccines built on emerging understanding of the human immune system. The Company's additional founders include Dr. David Baltimore
David Baltimore
David Baltimore is an American biologist, university administrator, and Nobel laureate in Physiology or Medicine. He served as president of the California Institute of Technology from 1997 to 2006, and is currently the Robert A. Millikan Professor of Biology at Caltech...
, Nobel Laureate, former president of Caltech, and a leading immunologist; Dr. Steven Reed, founder of the Infectious Disease Research Institute
Infectious Disease Research Institute
The Infectious Disease Research Institute is a non-profit organization based in Seattle, Washington and which conducts global health research on infectious diseases.-Malaria vaccine:...
(IDRI), Dr. Lili Yang of Caltech, and Dr. Pin Wang of University of Southern California
University of Southern California
The University of Southern California is a private, not-for-profit, nonsectarian, research university located in Los Angeles, California, United States. USC was founded in 1880, making it California's oldest private research university...
. On July 30, 2010, Dr Corey was named the fourth president of the Fred Hutchinson Cancer Research Center
Fred Hutchinson Cancer Research Center
The Fred Hutchinson Cancer Research Center, is one of the world’s leading cancer research institutes...
.
Corey received a B.A. (1967) and M.D. (1971) from the University of Michigan
University of Michigan
The University of Michigan is a public research university located in Ann Arbor, Michigan in the United States. It is the state's oldest university and the flagship campus of the University of Michigan...
, and received postgraduate training at the University of Michigan, University of Washington, and the U. S. Centers for Disease Control and Prevention
Centers for Disease Control and Prevention
The Centers for Disease Control and Prevention are a United States federal agency under the Department of Health and Human Services headquartered in Druid Hills, unincorporated DeKalb County, Georgia, in Greater Atlanta...
. In addition to his professorships at the University of Washington, Corey is currently principal investigator of the US HIV Vaccine Trials Network
HIV Vaccine Trials Network
The HIV Vaccine Trials Network is a non-profit organization which connects physicians and scientists with activists and community educators for the purpose of conducting clinical trials seeking a safe and effective HIV vaccine. Collaboratively, research professionals and laypeople review...
and holder of the Lawrence Corey Endowed Chair in Medical Virology at the University of Washington. In 2008, he was elected to the Institute of Medicine
Institute of Medicine
The Institute of Medicine is a not-for-profit, non-governmental American organization founded in 1970, under the congressional charter of the National Academy of Sciences...
of the (US) National Academy of Sciences
United States National Academy of Sciences
The National Academy of Sciences is a corporation in the United States whose members serve pro bono as "advisers to the nation on science, engineering, and medicine." As a national academy, new members of the organization are elected annually by current members, based on their distinguished and...
. Dr. Corey is one of the most highly cited and funded investigators in the United States. He has authored 12 books and more than 600 scientific publications and is a member of numerous scientific committees and editorial boards, including the National Cancer Institute
National Cancer Institute
The National Cancer Institute is part of the National Institutes of Health , which is one of 11 agencies that are part of the U.S. Department of Health and Human Services. The NCI coordinates the U.S...
Board of Scientific Counselors for Basic Sciences.
Research
Corey’s early research dealt with various areas of virology, including identification of diagnostic methods for genital herpes and participation in development of effective treatments. Between 1988-1998, Corey published a series of key studies showing the association between infection with herpes simplex virus type 2 (HSV-2) and HIV-1,These studies led to pilot and large sale clinical trials of anti-HSV-2 therapy to reduce HIV acquisition and transmission Corey also published landmark papers showing the effectiveness of acyclovir in the treatment of genital herpes,
His current work includes the coordination of clinical trials sites and laboratories for Phase 1-3 trials of HIV vaccines. He continues to do research in defining persistent reservoirs of HIV infection, prevention of CMV and HHV-6 infections in immunocompromised hosts, epidemiological studies of the relationship between HSV and HIV infection, and, in general, development of new technologies for the diagnosis and treatment of viral infections.
Honors
Dr. Corey is a member of the editorial board of the New England Journal of MedicineNew England Journal of Medicine
The New England Journal of Medicine is an English-language peer-reviewed medical journal published by the Massachusetts Medical Society. It describes itself as the oldest continuously published medical journal in the world.-History:...
. He is a fellow of the Infectious Diseases Society of America and a member of the American Epidemiological Society, American Society for Clinical Investigation
American Society for Clinical Investigation
The American Society for Clinical Investigation, or ASCI, established in 1908, is one of the nation's oldest and most respected medical honor societies.-Organization and Purpose:...
, and the Association of American Physicians
Association of American Physicians
The Association of American Physicians is a medical society founded in 1885 by the Canadian physician Sir William Osler and six other distinguished physicians of his era, for "the advancement of scientific and practical medicine." Election to the AAP is an honor extended to individuals with...
. In addition, he is the recipient of the Pan American Society’s Clinical Virology Award, the American Society for STD Research’s Parran Award, and the University of Michigan Medical School’s Distinguished Alumnus Award.
Selected works
Casper C, Krantz E, Selke S, Kuntz S, Wang J, Huang ML, Pauk JS, Corey L, Wald A (2007) Frequent asymptomatic mucosal replication of human herpesvirus 8 in immunocompetent men, The Journal of Infectious Diseases, 195 (30-36).Lazaro CA, Chang M, Tang W, Campbell J, Sullivan DG, Gretch DR, Corey L, Coombs RW (2007) Hepatitis C virus replication in transfected and serum-infected cultured human fetal hepatocytes, The American Journal of Pathology, 170 (478-489).
Zerr DM, Meier AS, Selke SS, Frenkel LM, Huang ML, Wald A, Rhoads M, Nguy L, Bornemann R, Morrow RA, Corey L (2005) A population-based study of primary human herpesvirus 6 infection, The New England Journal of Medicine, 352, 768-776.
Corey L, Wald A, Patel R, Sacks SL, Tyring SK, Warren T, Douglas JM Jr, Paavonen J, Morrow RA, Beutner KR, Stratchounsky LS, Mertz G, Keene ON, Watson HA, Tait D, Vargas-Cortes M; Valacyclovir HSV Transmission Study Group (2004) Once daily valacyclovir to reduce the risk of transmission of genital herpes, The New England Journal of Medicine, 350, 11-20.
Klausner RD, Fauci AS, Corey L, Nabel GJ, Gayle H, Berkley S, Haynes BF, Baltimore D, Collins C, Douglas RG, Esparza J, Francis DP, Ganguly NK, Gerberding JL, Johnston MI, Kazatchkine MD, McMichael AJ, Makgoba MW, Pantaleo G, Piot P, Shao Y, Tramont E, Varmus H, Wasserheit JN (2003) The need for a global HIV vaccine enterprise, Science, 300, 2036-2039.
Wald A, Langenberg AGM, Link K, Izu A, Ashley R, Warren T, Tyring S, Douglas JM, Corey L (2001) Effect of condoms on reducing the transmission of herpes simplex virus type-2 from men to women, JAMA, 285, 3100-3106
Wald A, Zeh J, Selke S, Warren T, Ryncarz AJ, Ashley R, Krieger JN, Corey L (2000) Reactivation of genital herpes simplex virus type 2 infection in asymptomatic seropositive persons, The New England Journal of Medicine, 342(12), 844-50
McElrath M J, Corey L, Greenberg P D, Matthews T J, Montefiori D C, Rowen L, Hood L, Mullins JI (1996). Human immunodeficiency virus type 1 infection despite prior immunization with a recombinant envelope vaccine regimen, Proceedings of the National Academy of Sciences (USA), 93(9), 3972-7.