A substituted benzamide anti-psychotic, reported to be a selective antagonist of dopamine D2 receptors activity on both central and peripheral levels.It is an atypical neuroleptic and a prokinetic agent. Levosulpiride is also claimed to have mood elevating properties. Levosulpiride is used in the treatment of psychoses, particularly negative symptoms of schizophrenia, anxiety disorders, dysthymia, vertigo, dyspepsia, irritable bowel syndrome and premature ejaculation.

In a dose range of 25-200 mg/day in divided doses, Levosulpiride is therapeutic for negative and cognitive symptoms of schizophrenia, and for
depressive and somatoform disorders.
Levosulpiride is an antipsychotic

Antipsychotic

An antipsychotic is a tranquilizing psychiatric medication primarily used to manage psychosis , particularly in schizophrenia and bipolar disorder. A first generation of antipsychotics, known as typical antipsychotics, was discovered in the 1950s...

 and prokinetic agent. It is the (S)-enantiomer

Enantiomer

In chemistry, an enantiomer is one of two stereoisomers that are mirror images of each other that are non-superposable , much as one's left and right hands are the same except for opposite orientation. It can be clearly understood if you try to place your hands one over the other without...

 of sulpiride

Sulpiride

Sulpiride is an...

.
It is sold in Spain under the brand name Levogastrol.

Levosulpiride Adverse Reactions / Levosulpiride Side Effects

Amenorrhoea, gynaecomastia, galactorrhoea, changes in libido.

Potentially Fatal: Neuroleptic malignant syndrome.

Special Precautions

May impair ability to drive or operate machinery. Pregnancy and lactation.
Other Drug Interactions

Reduced bioavailability with sucralfate, aluminium- and magnesium-containing antacids. Effect on GI motility may be antagonised by anticholinergic agents, narcotics and analgesics. Avoid alcohol.