Limb bud
Encyclopedia
In embryology
Embryology
Embryology is a science which is about the development of an embryo from the fertilization of the ovum to the fetus stage...

, the limb bud is a structure formed by the developing limb, derived from lateral plate mesoderm
Lateral plate mesoderm
Lateral plate mesoderm is a type of mesoderm that is found at the periphery of the embryo.-Division into layers:It will split into two layers, the somatic layer/mesoderm and the splanchnic layer/mesoderm...

. It is intimately related with the apical ectodermal ridge, which secretes factors (fibroblast growth factors [FGF] for example) inducing the initial differentiation of the limb bud. In turn, the mesodermal tissue of the limb bud secretes factors sustaining the development of the Apical Ectodermal Ridge.
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