Lipoglycopeptides are a class of antibiotic

Antibiotic

An antibacterial is a compound or substance that kills or slows down the growth of bacteria.The term is often used synonymously with the term antibiotic; today, however, with increased knowledge of the causative agents of various infectious diseases, antibiotic has come to denote a broader range of...

 that have lipophilic

Lipophilic

Lipophilicity, , refers to the ability of a chemical compound to dissolve in fats, oils, lipids, and non-polar solvents such as hexane or toluene. These non-polar solvents are themselves lipophilic — the axiom that like dissolves like generally holds true...

 side-chains linked to glycopeptide

Glycopeptide

Glycopeptides are peptides that contain carbohydrate moieties covalently attached to the side chains of the amino acid residues that constitute the peptide. Over the past few decades it has been recognised that glycans on cell surface and those bound to proteins play a critical role in biology...

s. The class includes oritavancin

Oritavancin

Oritavancin is a novel semi-synthetic glycopeptide antibiotic being developed for the treatment of serious Gram-positive infections...

, telavancin

Telavancin

Telavancin is a bactericidal lipoglycopeptide for use in MRSA or other Gram-positive infections. Telavancin is a synthetic derivative of vancomycin....

 and dalbavancin

Dalbavancin

Dalbavancin is a novel second-generation lipoglycopeptide antibiotic. It belongs to the same class as vancomycin, the most widely-used and one of the few treatments available to patients infected with methicillin-resistant Staphylococcus aureus .Dalbavancin is a novel semisynthetic...

.
Telavancin is the most potent of the 3 against Clostridium

Clostridium

Clostridium is a genus of Gram-positive bacteria, belonging to the Firmicutes. They are obligate anaerobes capable of producing endospores. Individual cells are rod-shaped, which gives them their name, from the Greek kloster or spindle...

 spp.

Approvals and clinical trials

Telavancin

Telavancin

Telavancin is a bactericidal lipoglycopeptide for use in MRSA or other Gram-positive infections. Telavancin is a synthetic derivative of vancomycin....

 has completed 4 phase III trials. and gained FDA approval in September 2009 for complicated skin and skin structure infections (cSSSI).

Oritavancin

Oritavancin

Oritavancin is a novel semi-synthetic glycopeptide antibiotic being developed for the treatment of serious Gram-positive infections...

 has completed a phase II trial.
it doesn't have US or European approval for marketing for clinical use. (In December 2008 the FDA declined to approve it, and an EU application was withdrawn.)

Dalbavancin

Dalbavancin

Dalbavancin is a novel second-generation lipoglycopeptide antibiotic. It belongs to the same class as vancomycin, the most widely-used and one of the few treatments available to patients infected with methicillin-resistant Staphylococcus aureus .Dalbavancin is a novel semisynthetic...

was undergoing a phase II trial, due to end in 2003. it doesn't have US or European approval for marketing for clinical use.