List of EC numbers (EC 6)
Encyclopedia
This list contains a list of EC numbers for the sixth group, EC 6, ligases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology
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EC 6.1.1: Ligases Forming Aminoacyl-tRNA and Related Compounds (Aminoacyl tRNA synthetase
: tyrosine-tRNA ligase
: tryptophan-tRNA ligase
: threonine-tRNA ligase
: leucine-tRNA ligase
: isoleucine-tRNA ligase
: lysine-tRNA ligase
: alanine-tRNA ligase
: Deleted: valine-tRNA ligase
: methionine-tRNA ligase
: serine-tRNA ligase
: aspartate-tRNA ligase
: D-alanine-poly(phosphoribitol) ligase
: glycine-tRNA ligase
: proline-tRNA ligase
: cysteine-tRNA ligase
: glutamate-tRNA ligase
: glutamine-tRNA ligase
: arginine-tRNA ligase
: phenylalanine-tRNA ligase
: histidine-tRNA ligase
: asparagine-tRNA ligase
: aspartate-tRNAAsn ligase
: glutamate-tRNAGln ligase
: lysine-tRNAPyl ligase
: long-chain-fatty-acid-CoA ligase: succinate-CoA ligase (GDP-forming)
: succinate-CoA ligase (ADP-forming)
: glutarate-CoA ligase
: cholate-CoA ligase: oxalate-CoA ligase
: malate-CoA ligase
: acid-CoA ligase (GDP-forming)
: biotin-CoA ligase
: 4-coumarate-CoA ligase
: acetate-CoA ligase (ADP-forming)
: 6-carboxyhexanoate-CoA ligase
: arachidonate-CoA ligase
: acetoacetate-CoA ligase
: propionate-CoA ligase
: citrate-CoA ligase
: long-chain-fatty-acid-luciferin-component ligase
: long-chain-fatty-acid-(acyl-carrier-protein) ligase
: Covered by EC 6.2.1.30: (citrate (pro-3S)-lyase) ligase
: dicarboxylate-CoA ligase
: phytanate-CoA ligase
: benzoate-CoA ligase
: o-succinylbenzoate-CoA ligase
: 4-hydroxybenzoate-CoA ligase
: 3a,7a-dihydroxy-5b-cholestanate-CoA ligase: Deleted, now EC 6.2.1.7: phenylacetate-CoA ligase
: 2-furoate-CoA ligase
: anthranilate-CoA ligase
: 4-chlorobenzoate-CoA ligase
: trans-feruloyl-CoA synthase
: glutamate-ammonia ligase: Now EC 6.3.4.13: aspartate-ammonia ligase (ADP-forming)
: NAD+ synthase
: glutamate-ethylamine ligase
: 4-methyleneglutamate-ammonia ligase
: glutathionylspermidine synthase
: trypanothione synthase
: adenosylcobinamide-phosphate synthase: glutamate-putrescine ligase
: glutathione synthase
: D-alanine-D-alanine ligase
: phosphopantothenate-cysteine ligase
: phosphoribosylaminoimidazolesuccinocarboxamide synthase
: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase
: UDP-N-acetylmuramate-L-alanine ligase
: UDP-N-acetylmuramoylalanine-D-glutamate ligase: UDP-N-acetylmuramoylalanyl-tripeptide-D-alanyl-D-alanine ligase: carnosine synthase
: dihydrofolate synthase
: UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diamino-pimelate ligase: 2,3-dihydroxybenzoate-serine ligase
: Deleted, due to EC 6.3.2.10: D-alanine-alanyl-poly(glycerolphosphate) ligase
: tetrahydrofolate synthase
: g-glutamylhistamine synthase: ubiquitin-protein ligase: indoleacetate-lysine synthetase
: ubiquitin-calmodulin ligase
: diphthine-ammonia ligase
: homoglutathione synthase
: tyrosine-arginine ligase
: tubulin-tyrosine ligase
: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
: aerobactin synthase
: dethiobiotin synthase
: (carboxyethyl)arginine b-lactam-synthase
: CTP synthase
: formate-tetrahydrofolate ligase
: adenylosuccinate synthase
: argininosuccinate synthase: urea carboxylase
: ribose-5-phosphate-ammonia ligase
: imidazoleacetate-phosphoribosyldiphosphate ligase
: biotin-(methylmalonyl-CoA-carboxytransferase) ligase
: biotin-(propionyl-CoA-carboxylase (ATP-hydrolysing)) ligase
: biotin-(methylcrotonoyl-CoA-carboxylase) ligase
: glutamate-methylamine ligase
: phosphoribosylamine-glycine ligase
: biotin carboxylase
: biotin-(acetyl-CoA-carboxylase) ligase
: carbamoyl-phosphate synthase (ammonia): formate-dihydrofolate ligase
: GMP synthase (glutamine-hydrolysing): phosphoribosylformylglycinamidine synthase
: asparagine synthase (glutamine-hydrolysing): carbamoyl-phosphate synthase (glutamine-hydrolysing): asparaginyl-tRNA synthase (glutamine-hydrolysing)
: glutaminyl-tRNA synthase (glutamine-hydrolysing)
: aminodeoxychorismate synthase
: hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)
: adenosylcobyric acid synthase (glutamine-hydrolysing)
: acetyl-CoA carboxylase
: propionyl-CoA carboxylase
: methylcrotonoyl-CoA carboxylase: geranoyl-CoA carboxylase
: acetone carboxylase
: RNA-3'-phosphate cyclase
: cobaltochelatase
International Union of Biochemistry and Molecular Biology
The International Union of Biochemistry and Molecular Biology is an international non-governmental organisation concerned with biochemistry and molecular biology...
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EC 6.1.1: Ligases Forming Aminoacyl-tRNA and Related Compounds (Aminoacyl tRNA synthetaseAminoacyl tRNA synthetaseAn aminoacyl tRNA synthetase is an enzyme that catalyzes the esterification of a specific amino acid or its precursor to one of all its compatible cognate tRNAs to form an aminoacyl-tRNA. This is sometimes called "charging" the tRNA with the amino acid...
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: tyrosine-tRNA ligaseTyrosine-tRNA ligase
In enzymology, a tyrosine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-tyrosine, and RNA, whereas its 3 products are AMP, triphosphate, and L-tyrosyl-tRNA....
: tryptophan-tRNA ligase
Tryptophan-tRNA ligase
In enzymology, a tryptophan-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-tryptophan, and tRNA, whereas its 3 products are AMP, diphosphate, and L-tryptophyl-tRNATrp....
: threonine-tRNA ligase
Threonine-tRNA ligase
In enzymology, a threonine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-threonine, and tRNA, whereas its 3 products are AMP, diphosphate, and L-threonyl-tRNA....
: leucine-tRNA ligase
Leucine-tRNA ligase
In enzymology, a leucine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-leucine, and tRNA, whereas its 3 products are AMP, diphosphate, and L-leucyl-tRNA....
: isoleucine-tRNA ligase
Isoleucine-tRNA ligase
In enzymology, an isoleucine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-isoleucine, and tRNA, whereas its 3 products are AMP, diphosphate, and L-isoleucyl-tRNA....
: lysine-tRNA ligase
Lysine-tRNA ligase
In enzymology, a lysine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-lysine, and tRNA, whereas its 3 products are AMP, diphosphate, and L-lysyl-tRNA....
: alanine-tRNA ligase
Alanine-tRNA ligase
In enzymology, an alanine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-alanine, and tRNA, whereas its 3 products are AMP, diphosphate, and L-alanyl-tRNA....
: Deleted: valine-tRNA ligase
Valine-tRNA ligase
In enzymology, a valine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-valine, and tRNA, whereas its 3 products are AMP, diphosphate, and L-valyl-tRNA....
: methionine-tRNA ligase
Methionine-tRNA ligase
In enzymology, a methionine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-methionine, and tRNA, whereas its 3 products are AMP, diphosphate, and L-methionyl-tRNA....
: serine-tRNA ligase
Serine-tRNA ligase
In enzymology, a serine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-serine, and tRNA, whereas its 3 products are AMP, diphosphate, and L-seryl-tRNA....
: aspartate-tRNA ligase
Aspartate-tRNA ligase
In enzymology, an aspartate-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-aspartate, and tRNA, whereas its 3 products are AMP, diphosphate, and L-aspartyl-tRNA....
: D-alanine-poly(phosphoribitol) ligase
D-alanine-poly(phosphoribitol) ligase
In enzymology, a D-alanine—poly ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, D-alanine, and poly, whereas its 3 products are AMP, diphosphate, and O-D-alanyl-poly.This enzyme belongs to the family of ligases, to be specific those forming...
: glycine-tRNA ligase
Glycine-tRNA ligase
In enzymology, a glycine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, glycine, and tRNA, whereas its 3 products are AMP, diphosphate, and glycyl-tRNA....
: proline-tRNA ligase
Proline-tRNA ligase
In enzymology, a proline—tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-proline, and tRNA, whereas its 3 products are AMP, diphosphate, and L-prolyl-tRNA....
: cysteine-tRNA ligase
Cysteine-tRNA ligase
In enzymology, a cysteine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-cysteine, and tRNA, whereas its 3 products are AMP, diphosphate, and L-cysteinyl-tRNA....
: glutamate-tRNA ligase
Glutamate-tRNA ligase
In enzymology, a glutamate-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-glutamate, and tRNA, whereas its 3 products are AMP, diphosphate, and L-glutamyl-tRNA....
: glutamine-tRNA ligase
Glutamine-tRNA ligase
In enzymology, a glutamine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-glutamine, and tRNA, whereas its 3 products are AMP, diphosphate, and L-glutaminyl-tRNA....
: arginine-tRNA ligase
Arginine-tRNA ligase
In enzymology, an arginine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-arginine, and tRNA, whereas its 3 products are AMP, diphosphate, and L-arginyl-tRNA....
: phenylalanine-tRNA ligase
Phenylalanine-tRNA ligase
In enzymology, a phenylalanine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-phenylalanine, and tRNA, whereas its 3 products are AMP, diphosphate, and L-phenylalanyl-tRNA....
: histidine-tRNA ligase
Histidine-tRNA ligase
In enzymology, a histidine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-histidine, and tRNA, whereas its 3 products are AMP, diphosphate, and L-histidyl-tRNA....
: asparagine-tRNA ligase
Asparagine-tRNA ligase
In enzymology, an asparagine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-asparagine, and tRNA, whereas its 3 products are AMP, diphosphate, and L-asparaginyl-tRNA....
: aspartate-tRNAAsn ligase
Aspartate-tRNAAsn ligase
In enzymology, an aspartate-tRNAAsn ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-aspartate, and tRNAAsx, whereas its 3 products are AMP, diphosphate, and aspartyl-tRNAAsx....
: glutamate-tRNAGln ligase
Glutamate-tRNAGln ligase
In enzymology, a glutamate-tRNAGln ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-glutamate, and tRNAGlx, whereas its 3 products are AMP, diphosphate, and glutamyl-tRNAGlx....
: lysine-tRNAPyl ligase
Lysine-tRNAPyl ligase
In enzymology, a lysine-tRNAPyl ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-lysine, and tRNA, whereas its 3 products are AMP, diphosphate, and L-lysyl-tRNA....
EC 6.2.1: Acid-Thiol Ligases
: acetate-CoA ligase: butyrate-CoA ligaseButyrate-CoA ligase
In enzymology, a butyrate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, acid, and CoA, whereas its 3 products are AMP, diphosphate, and acyl-CoA....
: long-chain-fatty-acid-CoA ligase: succinate-CoA ligase (GDP-forming)
Succinate-CoA ligase (GDP-forming)
In enzymology, a succinate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are GTP, succinate, and CoA, whereas its 3 products are GDP, phosphate, and succinyl-CoA....
: succinate-CoA ligase (ADP-forming)
Succinate-CoA ligase (ADP-forming)
In enzymology, a succinate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, succinate, and CoA, whereas its 3 products are ADP, phosphate, and succinyl-CoA....
: glutarate-CoA ligase
Glutarate-CoA ligase
In enzymology, a glutarate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, glutarate, and CoA, whereas its 3 products are ADP, phosphate, and glutaryl-CoA....
: cholate-CoA ligase: oxalate-CoA ligase
Oxalate-CoA ligase
In enzymology, an oxalate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, oxalate, and CoA, whereas its 3 products are AMP, diphosphate, and oxalyl-CoA....
: malate-CoA ligase
Malate-CoA ligase
In enzymology, a malate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, malate, and CoA, whereas its 3 products are ADP, phosphate, and malyl-CoA....
: acid-CoA ligase (GDP-forming)
Acid-CoA ligase (GDP-forming)
In enzymology, an acid-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are GTP, acid, and CoA, whereas its 3 products are GDP, phosphate, and acyl-CoA....
: biotin-CoA ligase
Biotin-CoA ligase
In enzymology, a biotin-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, biotin, and CoA, whereas its 3 products are AMP, diphosphate, and biotinyl-CoA....
: 4-coumarate-CoA ligase
4-coumarate-CoA ligase
In enzymology, a 4-coumarate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, 4-coumarate, and CoA, whereas its 3 products are AMP, diphosphate, and 4-coumaroyl-CoA....
: acetate-CoA ligase (ADP-forming)
Acetate-CoA ligase (ADP-forming)
In enzymology, an acetate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, acetate, and CoA, whereas its 3 products are ADP, phosphate, and acetyl-CoA....
: 6-carboxyhexanoate-CoA ligase
6-carboxyhexanoate-CoA ligase
In enzymology, a 6-carboxyhexanoate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, 6-carboxyhexanoate, and CoA, whereas its 3 products are AMP, diphosphate, and 6-carboxyhexanoyl-CoA....
: arachidonate-CoA ligase
Arachidonate-CoA ligase
In enzymology, an arachidonate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, arachidonate, and CoA, whereas its 3 products are AMP, diphosphate, and arachidonoyl-CoA....
: acetoacetate-CoA ligase
Acetoacetate-CoA ligase
In enzymology, an acetoacetate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, acetoacetate, and CoA, whereas its 3 products are AMP, diphosphate, and acetoacetyl-CoA....
: propionate-CoA ligase
Propionate-CoA ligase
In enzymology, a propionate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, propanoate, and CoA, whereas its 3 products are AMP, diphosphate, and propanoyl-CoA....
: citrate-CoA ligase
Citrate-CoA ligase
In enzymology, a citrate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, citrate, and CoA, whereas its 3 products are ADP, phosphate, and -citryl-CoA....
: long-chain-fatty-acid-luciferin-component ligase
Long-chain-fatty-acid-luciferin-component ligase
In enzymology, a long-chain-fatty-acid-luciferin-component ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, acid, and protein, whereas its 3 products are AMP, diphosphate, and acyl-protein thioester....
: long-chain-fatty-acid-(acyl-carrier-protein) ligase
Long-chain-fatty-acid-(acyl-carrier-protein) ligase
In enzymology, a long-chain-fatty-acid-[acyl-carrier-protein] ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, acid, and acyl-carrier-protein, whereas its 3 products are AMP, diphosphate, and acyl-[acyl-carrier-protein].This enzyme belongs to the...
: Covered by EC 6.2.1.30: (citrate (pro-3S)-lyase) ligase
(citrate (pro-3S)-lyase) ligase
In enzymology, a citrate -lyase ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, acetate, and citrate -lyase, whereas its 3 products are AMP, diphosphate, and citrate -lyase.This enzyme belongs to the family of ligases, specifically those forming...
: dicarboxylate-CoA ligase
Dicarboxylate-CoA ligase
In enzymology, a dicarboxylate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, alphaomega-dicarboxylic acid, and CoA, whereas its 3 products are AMP, diphosphate, and omega-carboxyacyl-CoA....
: phytanate-CoA ligase
Phytanate-CoA ligase
In enzymology, a phytanate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, phytanate, and CoA, whereas its 3 products are AMP, diphosphate, and phytanoyl-CoA....
: benzoate-CoA ligase
Benzoate-CoA ligase
In enzymology, a benzoate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, benzoate, and CoA, whereas its 3 products are AMP, diphosphate, and benzoyl-CoA....
: o-succinylbenzoate-CoA ligase
O-succinylbenzoate-CoA ligase
In enzymology, an o-succinylbenzoate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, o-succinylbenzoate, and CoA, whereas its 3 products are AMP, diphosphate, and o-succinylbenzoyl-CoA....
: 4-hydroxybenzoate-CoA ligase
4-hydroxybenzoate-CoA ligase
In enzymology, a 4-hydroxybenzoate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, 4-hydroxybenzoate, and CoA, whereas its 3 products are AMP, diphosphate, and 4-hydroxybenzoyl-CoA....
: 3a,7a-dihydroxy-5b-cholestanate-CoA ligase: Deleted, now EC 6.2.1.7: phenylacetate-CoA ligase
Phenylacetate-CoA ligase
In enzymology, a phenylacetate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, phenylacetate, and CoA, whereas its 3 products are AMP, diphosphate, and phenylacetyl-CoA....
: 2-furoate-CoA ligase
2-furoate-CoA ligase
In enzymology, a 2-furoate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, 2-furoate, and CoA, whereas its 3 products are AMP, diphosphate, and 2-furoyl-CoA....
: anthranilate-CoA ligase
Anthranilate-CoA ligase
In enzymology, an anthranilate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, anthranilate, and CoA, whereas its 3 products are AMP, diphosphate, and anthranilyl-CoA....
: 4-chlorobenzoate-CoA ligase
4-chlorobenzoate-CoA ligase
In enzymology, a 4-chlorobenzoate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are 4-chlorobenzoate, CoA, and ATP, whereas its 3 products are 4-chlorobenzoyl-CoA, AMP, and diphosphate....
: trans-feruloyl-CoA synthase
Trans-feruloyl-CoA synthase
In enzymology, a trans-feruloyl-CoA synthase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ferulic acid, CoASH, and ATP, whereas its two products are trans-feruloyl-CoA and products of ATP breakdown....
EC 6.3.1: Acid-Ammonia (or Amine) Ligases (Amide Synthases)
: aspartate-ammonia ligaseAspartate-ammonia ligase
In enzymology, an aspartate-ammonia ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-aspartate, and NH3, whereas its 3 products are AMP, diphosphate, and L-asparagine....
: glutamate-ammonia ligase: Now EC 6.3.4.13: aspartate-ammonia ligase (ADP-forming)
Aspartate-ammonia ligase (ADP-forming)
In enzymology, an aspartate-ammonia ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-aspartate, and NH3, whereas its 3 products are ADP, phosphate, and L-asparagine....
: NAD+ synthase
NAD+ synthase
In enzymology, a NAD+ synthase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, deamido-NAD+, and NH3, whereas its 3 products are AMP, diphosphate, and NAD+....
: glutamate-ethylamine ligase
Glutamate-ethylamine ligase
In enzymology, a glutamate-ethylamine ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-glutamate, and ethylamine, whereas its 3 products are ADP, phosphate, and N5-ethyl-L-glutamine....
: 4-methyleneglutamate-ammonia ligase
4-methyleneglutamate-ammonia ligase
In enzymology, a 4-methyleneglutamate-ammonia ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, 4-methylene-L-glutamate, and NH3, whereas its 3 products are AMP, diphosphate, and 4-methylene-L-glutamine....
: glutathionylspermidine synthase
Glutathionylspermidine synthase
In enzymology, a glutathionylspermidine synthase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are glutathione, spermidine, and ATP, whereas its 3 products are glutathionylspermidine, ADP, and phosphate....
: trypanothione synthase
Trypanothione synthase
In enzymology, a trypanothione synthase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are glutathione, glutathionylspermidine, and ATP, whereas its 3 products are N1,N8-bisspermidine, ADP, and phosphate....
: adenosylcobinamide-phosphate synthase: glutamate-putrescine ligase
Glutamate-putrescine ligase
In enzymology, a glutamate-putrescine ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-glutamate, and putrescine, whereas its 3 products are ADP, phosphate, and gamma-L-glutamylputrescine....
EC 6.3.2: Acid-Amino-Acid Ligases (Peptide Synthases)
: pantoate-b-alanine ligase: glutamate-cysteine ligaseGlutamate-cysteine ligase
In enzymology, a glutamate-cysteine ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-glutamate, and L-cysteine, whereas its 3 products are ADP, phosphate, and gamma-L-glutamyl-L-cysteine....
: glutathione synthase
Glutathione synthase
In enzymology, a glutathione synthase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, gamma-L-glutamyl-L-cysteine, and glycine, whereas its 3 products are ADP, phosphate, and glutathione....
: D-alanine-D-alanine ligase
D-alanine-D-alanine ligase
In enzymology, a D-alanine—D-alanine ligase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are ATP and D-alanine, whereas its 3 products are ADP, phosphate, and D-alanyl-D-alanine....
: phosphopantothenate-cysteine ligase
Phosphopantothenate-cysteine ligase
In enzymology, a phosphopantothenate-cysteine ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are CTP, -4'-phosphopantothenate, and L-cysteine, whereas its 3 products are CMP, diphosphate, and N-[-4'-phosphopantothenoyl]-L-cysteine.This enzyme belongs to the...
: phosphoribosylaminoimidazolesuccinocarboxamide synthase
Phosphoribosylaminoimidazolesuccinocarboxamide synthase
In enzymology, a phosphoribosylaminoimidazolesuccinocarboxamide synthase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, 5-amino-1-imidazole-4-carboxylate, and L-aspartate, whereas its 4 products are ADP, phosphate, -2-[5-amino-1-imidazole-4-, and...
: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase
In enzymology, an UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate, and L-lysine, whereas its 3 products are ADP, phosphate, and...
: UDP-N-acetylmuramate-L-alanine ligase
UDP-N-acetylmuramate-L-alanine ligase
In enzymology, an UDP-N-acetylmuramate-L-alanine ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, UDP-N-acetylmuramate, and L-alanine, whereas its 3 products are ADP, phosphate, and UDP-N-acetylmuramoyl-L-alanine.This enzyme belongs to the family of...
: UDP-N-acetylmuramoylalanine-D-glutamate ligase: UDP-N-acetylmuramoylalanyl-tripeptide-D-alanyl-D-alanine ligase: carnosine synthase
Carnosine synthase
In enzymology, a carnosine synthase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-histidine, and beta-alanine, whereas its 3 products are AMP, diphosphate, and carnosine....
: dihydrofolate synthase
Dihydrofolate synthase
In enzymology, a dihydrofolate synthase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, 7,8-dihydropteroate, and L-glutamate, whereas its 3 products are ADP, phosphate, and 7,8-dihydropteroylglutamate....
: UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diamino-pimelate ligase: 2,3-dihydroxybenzoate-serine ligase
2,3-dihydroxybenzoate-serine ligase
In enzymology, a 2,3-dihydroxybenzoate-serine ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, 2,3-dihydroxybenzoate, and L-serine, whereas its two products are products of ATP breakdown and N--L-serine.This enzyme belongs to the family of ligases,...
: Deleted, due to EC 6.3.2.10: D-alanine-alanyl-poly(glycerolphosphate) ligase
D-alanine-alanyl-poly(glycerolphosphate) ligase
In enzymology, a D-alanine-alanyl-poly ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, D-alanine, and alanyl-poly, whereas its 3 products are ADP, phosphate, and D-alanyl-alanyl-poly.This enzyme belongs to the family of ligases, specifically those...
: tetrahydrofolate synthase
Tetrahydrofolate synthase
In enzymology, a tetrahydrofolate synthase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, tetrahydropteroyl-[gamma-Glu]n, and L-glutamate, whereas its 3 products are ADP, phosphate, and tetrahydropteroyl-[gamma-Glu]n+1.This enzyme belongs to the family of...
: g-glutamylhistamine synthase: ubiquitin-protein ligase: indoleacetate-lysine synthetase
Indoleacetate-lysine synthetase
In enzymology, an indoleacetate-lysine synthetase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, acetate, and L-lysine, whereas its 3 products are ADP, phosphate, and N6-[acetyl]-L-lysine....
: ubiquitin-calmodulin ligase
Ubiquitin-calmodulin ligase
In enzymology, an ubiquitin-calmodulin ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, calmodulin, and ubiquitin, whereas its 3 products are AMP, diphosphate, and n-calmodulin....
: diphthine-ammonia ligase
Diphthine-ammonia ligase
In enzymology, a diphthine-ammonia ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, diphthine, and NH3, whereas its 3 products are ADP, phosphate, and diphthamide....
: homoglutathione synthase
Homoglutathione synthase
In enzymology, a homoglutathione synthase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, gamma-L-glutamyl-L-cysteine, and beta-alanine, whereas its 3 products are ADP, phosphate, and gamma-L-glutamyl-L-cysteinyl-beta-alanine.This enzyme belongs to the...
: tyrosine-arginine ligase
Tyrosine-arginine ligase
In enzymology, a tyrosine-arginine ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-tyrosine, and L-arginine, whereas its 3 products are AMP, diphosphate, and L-tyrosyl-L-arginine....
: tubulin-tyrosine ligase
Tubulin-tyrosine ligase
In enzymology, a tubulin-tyrosine ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, detyrosinated alpha-tubulin, and L-tyrosine, whereas its 3 products are alpha-tubulin, ADP, and phosphate....
: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
In enzymology, a N--L-cysteinyl-D-valine synthase is an enzyme that catalyzes the chemical reactionThe 5 substrates of this enzyme are ATP, L-2-aminohexanedioate, L-cysteine, L-valine, and H2O, whereas its 3 products are AMP, diphosphate, and...
: aerobactin synthase
Aerobactin synthase
In enzymology, an aerobactin synthase is an enzyme that catalyzes the chemical reactionThe 4 substrates of this enzyme are ATP, citrate, N6-acetyl-N6-hydroxy-L-lysine, and H2O, whereas its 3 products are ADP, phosphate, and aerobactin....
EC 6.3.3: Cyclo-Ligases
: phosphoribosylformylglycinamidine cyclo-ligase: 5-formyltetrahydrofolate cyclo-ligase5-formyltetrahydrofolate cyclo-ligase
In enzymology, a 5-formyltetrahydrofolate cyclo-ligase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are ATP and 5-formyltetrahydrofolate, whereas its 3 products are ADP, phosphate, and 5,10-methenyltetrahydrofolate.This enzyme belongs to the family of...
: dethiobiotin synthase
Dethiobiotin synthase
In enzymology, a dethiobiotin synthase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, 7,8-diaminononanoate, and CO2, whereas its 3 products are ADP, phosphate, and dethiobiotin....
: (carboxyethyl)arginine b-lactam-synthase
EC 6.3.4: Other Carbon-Nitrogen Ligases
: GMP synthaseGMP synthase
-Enzymology:In enzymology, a GMP synthase is an enzyme that catalyzes the chemical reactionThe 4 substrates of this enzyme are ATP, xanthosine 5'-phosphate, L-glutamine, and H2O, whereas its 4 products are AMP, diphosphate, GMP, and L-glutamate.This enzyme belongs to the family of ligases,...
: CTP synthase
CTP synthase
CTP synthase is an enzyme involved in pyrimidine biosynthesis that interconverts UTP and CTP.- Enzyme Structure :...
: formate-tetrahydrofolate ligase
Formate-tetrahydrofolate ligase
In enzymology, a formate-tetrahydrofolate ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, formate, and tetrahydrofolate, whereas its 3 products are ADP, phosphate, and 10-formyltetrahydrofolate....
: adenylosuccinate synthase
Adenylosuccinate synthase
In molecular biology, Adenylosuccinate synthase is an enzyme that plays an important role in purine biosynthesis, by catalysing the guanosine triphosphate -dependent conversion of inosine monophosphate and aspartic acid to guanosine diphosphate , phosphate and N--AMP...
: argininosuccinate synthase: urea carboxylase
Urea carboxylase
In enzymology, an urea carboxylase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, urea, and HCO3-, whereas its 3 products are ADP, phosphate, and urea-1-carboxylate ....
: ribose-5-phosphate-ammonia ligase
Ribose-5-phosphate-ammonia ligase
In enzymology, a ribose-5-phosphate-ammonia ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, ribose 5-phosphate, and NH3, whereas its 3 products are ADP, phosphate, and 5-phosphoribosylamine....
: imidazoleacetate-phosphoribosyldiphosphate ligase
Imidazoleacetate-phosphoribosyldiphosphate ligase
In enzymology, an imidazoleacetate-phosphoribosyldiphosphate ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, imidazole-4-acetate, and 5-phosphoribosyl diphosphate, whereas its 4 products are ADP, phosphate, 1-imidazole-4-acetate, and...
: biotin-(methylmalonyl-CoA-carboxytransferase) ligase
Biotin-(methylmalonyl-CoA-carboxytransferase) ligase
In enzymology, a biotin-[methylmalonyl-CoA-carboxytransferase] ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, biotin, and apo-[methylmalonyl-CoA:pyruvate carboxytransferase], whereas its 3 products are AMP, diphosphate, and...
: biotin-(propionyl-CoA-carboxylase (ATP-hydrolysing)) ligase
Biotin-(propionyl-CoA-carboxylase (ATP-hydrolysing)) ligase
In enzymology, a biotin-[propionyl-CoA-carboxylase ] ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, biotin, and apo-[propionyl-CoA:carbon-dioxide ligase , whereas its 3 products are AMP, diphosphate, and propionyl-CoA:carbon-dioxide ligase .This...
: biotin-(methylcrotonoyl-CoA-carboxylase) ligase
Biotin-(methylcrotonoyl-CoA-carboxylase) ligase
In enzymology, a biotin-[methylcrotonoyl-CoA-carboxylase] ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, biotin, and apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase ], whereas its 3 products are AMP, diphosphate, and...
: glutamate-methylamine ligase
Glutamate-methylamine ligase
In enzymology, a glutamate-methylamine ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-glutamate, and methylamine, whereas its 3 products are ADP, phosphate, and N5-methyl-L-glutamine....
: phosphoribosylamine-glycine ligase
Phosphoribosylamine-glycine ligase
In enzymology, a phosphoribosylamine-glycine ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, 5-phospho-D-ribosylamine, and glycine, whereas its 3 products are ADP, phosphate, and N1-glycinamide.This enzyme belongs to the family of ligases,...
: biotin carboxylase
Biotin carboxylase
In enzymology, a biotin carboxylase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, biotin-carboxyl-carrier protein, and CO2, whereas its 3 products are ADP, phosphate, and carboxybiotin-carboxyl-carrier protein....
: biotin-(acetyl-CoA-carboxylase) ligase
Biotin-(acetyl-CoA-carboxylase) ligase
In enzymology, a biotin-[acetyl-CoA-carboxylase] ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, biotin, and apo-[acetyl-CoA:carbon-dioxide ligase ], whereas its 3 products are AMP, diphosphate, and acetyl-CoA:carbon-dioxide ligase .This enzyme...
: carbamoyl-phosphate synthase (ammonia): formate-dihydrofolate ligase
Formate-dihydrofolate ligase
In enzymology, a formate—dihydrofolate ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, formate, and dihydrofolate, whereas its 3 products are ADP, phosphate, and 10-formyldihydrofolate....
EC 6.3.5: Carbon-Nitrogen Ligases with Glutamine as Amido-N-Donor
: NAD+ synthase (glutamine-hydrolysing)NAD+ synthase (glutamine-hydrolysing)
In enzymology, a NAD+ synthase is an enzyme that catalyzes the chemical reactionThe 4 substrates of this enzyme are ATP, deamido-NAD+, L-glutamine, and H2O, whereas its 4 products are AMP, diphosphate, NAD+, and L-glutamate....
: GMP synthase (glutamine-hydrolysing): phosphoribosylformylglycinamidine synthase
Phosphoribosylformylglycinamidine synthase
In enzymology, a phosphoribosylformylglycinamidine synthase is an enzyme that catalyzes the chemical reactionThe 4 substrates of this enzyme are ATP, N2-formyl-N1-glycinamide, L-glutamine, and H2O, whereas its 4 products are ADP, phosphate, 2--N1-acetamidine, and L-glutamate.This enzyme belongs to...
: asparagine synthase (glutamine-hydrolysing): carbamoyl-phosphate synthase (glutamine-hydrolysing): asparaginyl-tRNA synthase (glutamine-hydrolysing)
Asparaginyl-tRNA synthase (glutamine-hydrolysing)
In enzymology, an asparaginyl-tRNA synthase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, aspartyl-tRNA, and L-glutamine, whereas its 4 products are ADP, phosphate, asparaginyl-tRNA, and L-glutamate.This enzyme belongs to the family of ligases,...
: glutaminyl-tRNA synthase (glutamine-hydrolysing)
Glutaminyl-tRNA synthase (glutamine-hydrolysing)
In enzymology, a glutaminyl-tRNA synthase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, glutamyl-tRNA, and L-glutamine, whereas its 4 products are ADP, phosphate, glutaminyl-tRNA, and L-glutamate.This enzyme belongs to the family of ligases,...
: aminodeoxychorismate synthase
Aminodeoxychorismate synthase
In enzymology, an aminodeoxychorismate synthase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are chorismate and L-glutamine, whereas its two products are 4-amino-4-deoxychorismate and L-glutamate....
: hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)
Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)
In enzymology, a hydrogenobyrinic acid a,c-diamide synthase is an enzyme that catalyzes the chemical reactionThe 4 substrates of this enzyme are ATP, hydrogenobyrinic acid, L-glutamine, and H2O, whereas its 4 products are ADP, phosphate, hydrogenobyrinic acid a,c-diamide, and L-glutamate.This...
: adenosylcobyric acid synthase (glutamine-hydrolysing)
Adenosylcobyric acid synthase (glutamine-hydrolysing)
In enzymology, an adenosylcobyric acid synthase is an enzyme that catalyzes the chemical reactionThe 4 substrates of this enzyme are ATP, adenosylcobyrinic acid a,c-diamide, L-glutamine, and H2O, whereas its 4 products are ADP, phosphate, adenosylcobyric acid, and L-glutamate.This enzyme belongs...
EC 6.4: Forming Carbon-Carbon Bonds
: pyruvate carboxylasePyruvate carboxylase
Pyruvate carboxylase is an enzyme of the ligase class that catalyzes the irreversible carboxylation of pyruvate to form oxaloacetate .It is an important anaplerotic reaction that creates oxaloacetate from pyruvate...
: acetyl-CoA carboxylase
Acetyl-CoA carboxylase
Acetyl-CoA carboxylase is a biotin-dependent enzyme that catalyzes the irreversible carboxylation of acetyl-CoA to produce malonyl-CoA through its two catalytic activities, biotin carboxylase and carboxyltransferase...
: propionyl-CoA carboxylase
Propionyl-CoA carboxylase
Propionyl-CoA carboxylase catalyses the carboxylation reaction of propionyl CoA in the mitochondrial matrix. The enzyme is biotin dependent. The product of the reaction is -methylmalonyl CoA. Propionyl CoA is the end product of metabolism of odd-chain fatty acids, and is also a metabolite of most...
: methylcrotonoyl-CoA carboxylase: geranoyl-CoA carboxylase
Geranoyl-CoA carboxylase
In enzymology, a geranoyl-CoA carboxylase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, geranoyl-CoA, and HCO3-, whereas its 3 products are ADP, phosphate, and 3-pent-2-enedioyl-CoA....
: acetone carboxylase
Acetone carboxylase
In enzymology, an acetone carboxylase is an enzyme that catalyzes the chemical reactionThe 4 substrates of this enzyme are acetone, CO2, ATP, and H2O, whereas its 3 products are acetoacetate, AMP, and phosphate....
EC 6.5: Forming Phosphoric Ester Bonds
: DNA ligase (ATP): DNA ligase (NAD+): RNA ligase (ATP)RNA ligase (ATP)
In enzymology, an RNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, n, and m, whereas its 3 products are AMP, diphosphate, and n+m....
: RNA-3'-phosphate cyclase
RNA-3'-phosphate cyclase
In enzymology, a RNA-3'-phosphate cyclase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are ATP and RNA 3'-terminal-phosphate, whereas its 3 products are AMP, diphosphate, and RNA terminal-2',3'-cyclic-phosphate....
EC 6.6.1: Forming Coordination Complexes
: magnesium chelataseMagnesium chelatase
Magnesium-chelatase is a three-component enzyme that catalyses the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of bacteriochlorophyll...
: cobaltochelatase
Cobaltochelatase
Cobalt chelatase is an enzyme that catalyzes the chemical reactionThe 4 substrates of this enzyme are ATP, hydrogenobyrinic acid a,c-diamide, Co2+, and H2O, whereas its 4 products are ADP, phosphate, cobyrinic acid a,c-diamide, and H+....