Lithium tetramethylpiperidide
Encyclopedia
Lithium tetramethylpiperidide or LiTMP is an organic base
and a non-nucleophilic base. It is traditionally synthesised from 2,2,6,6-tetramethylpiperidine
and n-butyllithium
at -78 °C, but recent reports show this reaction is sluggish and is better formed at 0 °C. The compound is stable in a THF
/ethylbenzene
solvent mixture and commercially available as such. LiTMP has a pKa
of 37.
Base (chemistry)
For the term in genetics, see base A base in chemistry is a substance that can accept hydrogen ions or more generally, donate electron pairs. A soluble base is referred to as an alkali if it contains and releases hydroxide ions quantitatively...
and a non-nucleophilic base. It is traditionally synthesised from 2,2,6,6-tetramethylpiperidine
2,2,6,6-Tetramethylpiperidine
2,2,6,6-Tetramethylpiperidine or TMP or HTMP is a clear liquid with an amine odor. This amine is used in chemistry as a hindered base because it can dissolve in organic solvents unlike ordinary bases such as potassium hydroxide....
and n-butyllithium
N-Butyllithium
n-Butyllithium is an organolithium reagent. It is widely used as a polymerization initiator in the production of elastomers such as polybutadiene or styrene-butadiene-styrene...
at -78 °C, but recent reports show this reaction is sluggish and is better formed at 0 °C. The compound is stable in a THF
ThF
Follicular B helper T cells , are antigen-experienced CD4+ T cells found in the B cell follicles of secondary lymphoid organs such as lymph nodes, spleens and Peyer's patches, and are identified by their constitutive expression of the B cell follicle homing receptor CXCR5...
/ethylbenzene
Ethylbenzene
Ethylbenzene is an organic compound with the formula C6H5CH2CH3. This aromatic hydrocarbon is important in the petrochemical industry as an intermediate in the production of styrene, which in turn is used for making polystyrene, a common plastic material....
solvent mixture and commercially available as such. LiTMP has a pKa
PKA
PKA, pKa, or other similar variations may stand for:* pKa, the symbol for the acid dissociation constant at logarithmic scale* Protein kinase A, a class of cAMP-dependent enzymes* Pi Kappa Alpha, the North-American social fraternity...
of 37.