A local anesthetic with vasoconstrictor is a combination drug of a local anesthetic

Local anesthetic

A local anesthetic is a drug that causes reversible local anesthesia, generally for the aim of having local analgesic effect, that is, inducing absence of pain sensation, although other local senses are often affected as well...

 in order to induce absence of pain in an area, given with a vasoconstrictor in order to increase the duration of local anesthesia by constricting the blood vessels, thereby safely concentrating the anesthetic agent for an extended duration, as well as reducing hemorrhage.

Examples

• Prilocaine
  Prilocaine
  Prilocaine is a local anesthetic of the amino amide type first prepared by Claes Tegner and Nils Lofgren. In its injectable form , it is often used in dentistry. It is also often combined with lidocaine as a preparation for dermal anesthesia , for treatment of conditions like paresthesia...
  
  /epinephrine
  Epinephrine
  Epinephrine is a hormone and a neurotransmitter. It increases heart rate, constricts blood vessels, dilates air passages and participates in the fight-or-flight response of the sympathetic nervous system. In chemical terms, adrenaline is one of a group of monoamines called the catecholamines...
  
   (trade name Citanest Forte)
• Iontocaine
  Iontocaine
  Iontocaine, known by the brand name Numby, is a local anesthetic with vasoconstrictor, administered via iontophoresis through the skin. It can numb up to 10 mm of skin as quick as 10 minutes. It is a 2% lidocaine, 0.01 mg/ml epinephrine solution. It was manufactured by IOMED, Inc.Iontocaine was...
  
  , consisting of lidocaine
  Lidocaine
  Lidocaine , Xylocaine, or lignocaine is a common local anesthetic and antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic or as a local anesthetic for minor surgery.- History :Lidocaine, the first amino...
  
   and epinephrine
  Epinephrine
  Epinephrine is a hormone and a neurotransmitter. It increases heart rate, constricts blood vessels, dilates air passages and participates in the fight-or-flight response of the sympathetic nervous system. In chemical terms, adrenaline is one of a group of monoamines called the catecholamines...
  
  
• Septocaine (trade name Septodont), a combination of articaine and epinephrine

Contraindications

Local anesthetics with vasoconstrictors should not be used in the nose

Nose

Anatomically, a nose is a protuberance in vertebrates that houses the nostrils, or nares, which admit and expel air for respiration in conjunction with the mouth. Behind the nose are the olfactory mucosa and the sinuses. Behind the nasal cavity, air next passes through the pharynx, shared with the...

, fingers, toes and penis

Penis

The penis is a biological feature of male animals including both vertebrates and invertebrates...

, because the arteries here are end arteries

End artery

An end artery is an artery that is the only supply of oxygenated blood to a portion of tissue. End arteries are also known as terminal arteries....

, so the vasoconstrictor effect could cause ischemia

Ischemia

In medicine, ischemia is a restriction in blood supply, generally due to factors in the blood vessels, with resultant damage or dysfunction of tissue. It may also be spelled ischaemia or ischæmia...

 and even gangrene

Gangrene

Gangrene is a serious and potentially life-threatening condition that arises when a considerable mass of body tissue dies . This may occur after an injury or infection, or in people suffering from any chronic health problem affecting blood circulation. The primary cause of gangrene is reduced blood...

of the affected part. Rather, a local anesthetic without vasoconstrictor should be used for local anesthesia in such parts.