Lowest published toxic dose
Encyclopedia
In toxicology
, the Lowest published toxic dose (Toxic Dose Low, TDLo) is the lowest dosage
per unit of bodyweight (typically stated in milligrams per kilogram
) of a substance
known to have produced signs of toxicity
in a particular animal
species
. When quoting a TDLo, the particular species and method of administration (e.g. ingested, inhaled, intravenous) are typically stated.
Toxicology
Toxicology is a branch of biology, chemistry, and medicine concerned with the study of the adverse effects of chemicals on living organisms...
, the Lowest published toxic dose (Toxic Dose Low, TDLo) is the lowest dosage
Dose (biochemistry)
A dose is a quantity of something that may impact an organism biologically; the greater the quantity, the larger the dose. In nutrition, the term is usually applied to how much of a specific nutrient is in a person's diet or in a particular food, meal, or dietary supplement...
per unit of bodyweight (typically stated in milligrams per kilogram
Kilogram
The kilogram or kilogramme , also known as the kilo, is the base unit of mass in the International System of Units and is defined as being equal to the mass of the International Prototype Kilogram , which is almost exactly equal to the mass of one liter of water...
) of a substance
Chemical substance
In chemistry, a chemical substance is a form of matter that has constant chemical composition and characteristic properties. It cannot be separated into components by physical separation methods, i.e. without breaking chemical bonds. They can be solids, liquids or gases.Chemical substances are...
known to have produced signs of toxicity
Toxicity
Toxicity is the degree to which a substance can damage a living or non-living organisms. Toxicity can refer to the effect on a whole organism, such as an animal, bacterium, or plant, as well as the effect on a substructure of the organism, such as a cell or an organ , such as the liver...
in a particular animal
Animal
Animals are a major group of multicellular, eukaryotic organisms of the kingdom Animalia or Metazoa. Their body plan eventually becomes fixed as they develop, although some undergo a process of metamorphosis later on in their life. Most animals are motile, meaning they can move spontaneously and...
species
Species
In biology, a species is one of the basic units of biological classification and a taxonomic rank. A species is often defined as a group of organisms capable of interbreeding and producing fertile offspring. While in many cases this definition is adequate, more precise or differing measures are...
. When quoting a TDLo, the particular species and method of administration (e.g. ingested, inhaled, intravenous) are typically stated.
See also
- Certain safety factorCertain safety factorThe Certain Safety Factor is the ratio of the lethal dose to 1% of population to the effective dose to 99% of the population . This is a better safety index than the LD50 for materials that have both desirable and undesirable effects, because it factors in the ends of the spectrum where doses may...
- Lowest published lethal doseLowest published lethal doseIn toxicology, the LDLo is the lowest dosage per unit of bodyweight of a substance known to have resulted in fatality in a particular animal species...
(LDLo) - Median lethal dose (LD50)