Lucille is also the guitar played by Ryusuke, a main character from the manga

Manga

Manga is the Japanese word for "comics" and consists of comics and print cartoons . In the West, the term "manga" has been appropriated to refer specifically to comics created in Japan, or by Japanese authors, in the Japanese language and conforming to the style developed in Japan in the late 19th...

/anime

Anime

is the Japanese abbreviated pronunciation of "animation". The definition sometimes changes depending on the context. In English-speaking countries, the term most commonly refers to Japanese animated cartoons....

 series Beck. It is a Gibson Les Paul

Gibson Les Paul

The Gibson Les Paul was the result of a design collaboration between Gibson Guitar Corporation and the late jazz guitarist and electronics inventor Les Paul. In 1950, with the introduction of the Fender Telecaster to the musical market, electric guitars became a public craze. In reaction, Gibson...

 with bullet holes in the body. Lucille, and its history, are based heavily on that of B. B. King

B. B. King

Riley B. King , known by the stage name B.B. King, is an American blues guitarist and singer-songwriter.Rolling Stone magazine ranked him at No.3 on its list of the 100 greatest guitarists of all time. According to Edward M...

's guitar of the same name

Lucille (guitar)

Lucille is the name given to B.B. King's guitars. They are usually black Gibson guitars similar to the ES-355.-The story of Lucille:In the winter of 1949, King played at a dance hall in Twist, Arkansas. In order to heat the hall, a barrel half-filled with kerosene was lit, a fairly common practice...

. B. B. King was playing at a juke joint in the 1950s when a fire broke out. The fire was started by two men who were fighting over a woman named "Lucille". During their fight, they knocked over the bucket of burning kerosene used for heat. When King escaped the building, he realized that he had left his guitar in the burning building. He ran back inside to get it and after learning of what happened, he named his guitar, and every guitar he owned after, "Lucille" to remind himself not to do it again.

Lucille's owner in the show, sonny boy waters, is probably the amalgamation of several influential Blues musicians such as Sonny Boy Williamson II

Sonny Boy Williamson II

Willie "Sonny Boy" Williamson was an American blues harmonica player, singer and songwriter, from Mississippi. He is acknowledged as one of the most charismatic and influential blues musicians, with considerable prowess on the harmonica and highly creative songwriting skills...

, Muddy Waters

Muddy Waters

McKinley Morganfield , known as Muddy Waters, was an American blues musician, generally considered the "father of modern Chicago blues"...

 and Robert Johnson. Robert Johnson's death shares similarities with Sonny Boy's, having been shot and poisoned for fooling around with a married woman, while performing at a dance. Eric Clapton

Eric Clapton

Eric Patrick Clapton, CBE, is an English guitarist and singer-songwriter. Clapton is the only three-time inductee to the Rock and Roll Hall of Fame: once as a solo artist, and separately as a member of The Yardbirds and Cream. Clapton has been referred to as one of the most important and...

called Johnson "the most important blues musician who ever lived," fitting in even more with the information from the series.