Lysosome-associated membrane glycoprotein
Encyclopedia
Lysosome-associated membrane glycoproteins (lamp) are integral membrane proteins, specific to lysosomes, and whose exact biological function is not yet clear. Structurally, the lamp proteins consist of two internally homologous lysosome-luminal domains separated by a proline-rich hinge region; at the C-terminal extremity there is a transmembrane region (TM) followed by a very short cytoplasmic tail (C). In each of the duplicated domains, there are two conserved disulfide bond
s. This structure is schematically represented in the figure below.
+-----+ +-----+ +-----+ +-----+
| | | | | | | |
xCxxxxxCxxxxxxxxxxxxCxxxxxCxxxxxxxxxCxxxxxCxxxxxxxxxxxxCxxxxxCxxxxxxxx
+--------------------------++Hinge++--------------------------++TM++C+
In mammals, there are two closely related types of lamp: LAMP1
and LAMP2
.
CD69
(also called gp110 or macrosialin) is a heavily glycosylated integral membrane protein whose structure consists of a mucin-like domain followed by a proline-rich hinge; a single lamp-like domain; a transmembrane region and a short cytoplasmic tail.
CD molecules are leucocyte antigens on cell surfaces. CD antigens nomenclature is updated at Protein Reviews On The Web (http://mpr.nci.nih.gov/prow/).
Disulfide bond
In chemistry, a disulfide bond is a covalent bond, usually derived by the coupling of two thiol groups. The linkage is also called an SS-bond or disulfide bridge. The overall connectivity is therefore R-S-S-R. The terminology is widely used in biochemistry...
s. This structure is schematically represented in the figure below.
+-----+ +-----+ +-----+ +-----+
| | | | | | | |
xCxxxxxCxxxxxxxxxxxxCxxxxxCxxxxxxxxxCxxxxxCxxxxxxxxxxxxCxxxxxCxxxxxxxx
+--------------------------++Hinge++--------------------------++TM++C+
In mammals, there are two closely related types of lamp: LAMP1
LAMP1
Lysosomal-associated membrane protein 1 also known as CD107a , is a human gene.-External links:...
and LAMP2
LAMP2
Lysosomal-associated membrane protein 2 also known as CD107b , is a human gene....
.
CD69
CD69
CD69 is a human transmembrane C-Type lectin protein encoded by the gene.-Further reading:...
(also called gp110 or macrosialin) is a heavily glycosylated integral membrane protein whose structure consists of a mucin-like domain followed by a proline-rich hinge; a single lamp-like domain; a transmembrane region and a short cytoplasmic tail.
CD molecules are leucocyte antigens on cell surfaces. CD antigens nomenclature is updated at Protein Reviews On The Web (http://mpr.nci.nih.gov/prow/).