6,7-Methylenedioxy-2-aminotetralin (MDAT) is a drug

Drug

A drug, broadly speaking, is any substance that, when absorbed into the body of a living organism, alters normal bodily function. There is no single, precise definition, as there are different meanings in drug control law, government regulations, medicine, and colloquial usage.In pharmacology, a...

 developed in the 1990s by a team at Purdue University

Purdue University

Purdue University, located in West Lafayette, Indiana, U.S., is the flagship university of the six-campus Purdue University system. Purdue was founded on May 6, 1869, as a land-grant university when the Indiana General Assembly, taking advantage of the Morrill Act, accepted a donation of land and...

 led by David E. Nichols

David E. Nichols

David E. Nichols is an American pharmacologist and medicinal chemist.Presently the Robert C. and Charlotte P. Anderson Distinguished Chair in Pharmacology at Purdue University, Nichols has worked in the field of psychoactive drugs since 1969...

. It appears to act as a serotonin releasing agent

Serotonin releasing agent

A serotonin releasing agent is a type of drug which induces the release of serotonin from the pre-synaptic neuron into the synapse...

 based on rodent drug discrimination assays comparing it to MDMA, in which it fully substitutes for, and additionally lacks any kind of serotonergic

Serotonergic

Serotonergic or serotoninergic means "related to the neurotransmitter serotonin". A synapse is serotonergic if it uses serotonin as its neurotransmitter...

 neurotoxicity

Neurotoxicity

Neurotoxicity occurs when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system in such a way as to cause damage to nervous tissue. This can eventually disrupt or even kill neurons, key cells that transmit and process...

. Hence, MDAT is considered likely to be a non-neurotoxic, putative entactogen in humans.

See also

• 2-Aminotetralin
  2-Aminotetralin
  2-Aminotetralin , also known as 1,2,3,4-tetrahydronaphthalen-2-amine , is a stimulant drug with a chemical structure consisting of a tetralin group combined with an amine....
  
  
• MDMAT
• 6-CAT
• MDAI
  5,6-Methylenedioxy-2-aminoindane
  5,6-Methylenedioxy-2-aminoindane is a drug developed in the 1990s by a team led by David E. Nichols at Purdue University. It acts as a non-neurotoxic and highly selective serotonin releasing agent in vitro and produces entactogen effects in humans.- Chemistry :The chemical structure of MDAI is...
  
  
• MDMAI
  5,6-Methylenedioxy-N-methyl-2-aminoindane
  5,6-Methylenedioxy-N-methyl-2-aminoindane , is a drug developed in the 1990s by a team led by David E. Nichols at Purdue University...
  
  
• MMAI
  5-Methoxy-6-methyl-2-aminoindane
  5-Methoxy-6-methyl-2-aminoindane , is a drug developed in the 1990s by a team led by David E. Nichols at Purdue University. It acts as a non-neurotoxic and highly selective serotonin releasing agent and produces entactogen effects in humans...