MED4
Encyclopedia
Mediator of RNA polymerase II transcription subunit 4 also known as mediator complex subunit 4 (MED4) or vitamin D3 receptor-interacting protein complex 36 kDa component (DRIP36) is a protein
that in humans is encoded by the MED4 gene
.
encoded by this gene is a component of the vitamin D receptor-interacting protein (DRIP
) complex which functions as a nuclear receptor
coactivator
. The DRIP complex is capable of activating nuclear receptors in a ligand-dependent manner.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the MED4 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Function
The proteinProtein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
encoded by this gene is a component of the vitamin D receptor-interacting protein (DRIP
Mediator (coactivator)
Mediator is a multiprotein complex that functions as a transcriptional coactivator. It was discovered by Roger D. Kornberg, winner of the 2006 Nobel Prize in Chemistry...
) complex which functions as a nuclear receptor
Nuclear receptor
In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules...
coactivator
Coactivator (genetics)
A coactivator is a protein that increases gene expression by binding to an activator which contains a DNA binding domain. The coactivator is unable to bind DNA by itself....
. The DRIP complex is capable of activating nuclear receptors in a ligand-dependent manner.