Manchester score
Encyclopedia
Manchester score is an indicator of prognosis
Prognosis
Prognosis is a medical term to describe the likely outcome of an illness.When applied to large statistical populations, prognostic estimates can be very accurate: for example the statement "45% of patients with severe septic shock will die within 28 days" can be made with some confidence, because...

 in small cell lung cancer
Lung cancer
Lung cancer is a disease characterized by uncontrolled cell growth in tissues of the lung. If left untreated, this growth can spread beyond the lung in a process called metastasis into nearby tissue and, eventually, into other parts of the body. Most cancers that start in lung, known as primary...

. It is calculated from a number of physical and biochemical markers.

A patient with small cell lung cancer scores one point for each of the following: -
  • Serum
    Blood plasma
    Blood plasma is the straw-colored liquid component of blood in which the blood cells in whole blood are normally suspended. It makes up about 55% of the total blood volume. It is the intravascular fluid part of extracellular fluid...

     lactate dehydrogenase
    Lactate dehydrogenase
    Lactate dehydrogenase is an enzyme present in a wide variety of organisms, including plants and animals.Lactate dehydrogenases exist in four distinct enzyme classes. Two of them are cytochrome c-dependent enzymes, each acting on either D-lactate or L-lactate...

     exceeds the upper limit of the reference range.
  • Serum sodium
    Sodium
    Sodium is a chemical element with the symbol Na and atomic number 11. It is a soft, silvery-white, highly reactive metal and is a member of the alkali metals; its only stable isotope is 23Na. It is an abundant element that exists in numerous minerals, most commonly as sodium chloride...

     concentration less than 132 mmol/l.
  • Serum alkaline phosphatase
    Alkaline phosphatase
    Alkaline phosphatase is a hydrolase enzyme responsible for removing phosphate groups from many types of molecules, including nucleotides, proteins, and alkaloids. The process of removing the phosphate group is called dephosphorylation...

     over one-and-a-half times the upper limit of the reference range.
  • Serum bicarbonate
    Bicarbonate
    In inorganic chemistry, bicarbonate is an intermediate form in the deprotonation of carbonic acid...

     less than 24.
  • Karnofsky performance status
    Performance status
    In medicine , performance status is an attempt to quantify cancer patients' general well-being and activities of daily life. This measure is used to determine whether they can receive chemotherapy, whether dose adjustment is necessary, and as a measure for the required intensity of palliative care...

    less than 60.
  • Extensive stage disease.

Prognosis

Prognosis of small cell lung cancer according to Manchester score
Manchester score Prognostic group Two year survival (%)
0-1 Good 16.2
2-3 Medium 2.5
4 or more Poor 0
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