Marginal zone B-cell lymphoma
Encyclopedia
Marginal zone B-cell lymphoma is a type of B-cell lymphoma
presenting primarily in the marginal zone
.
There are three types:
All three are CD5
and CD10 negative
B-cell lymphoma
The B-cell lymphomas are types of lymphoma affecting B cells. Lymphomas are "blood cancers" in the lymph glands. They develop more frequently in older adults and in immunocompromised individuals ....
presenting primarily in the marginal zone
Marginal zone
The marginal zone is the region at the interface between the non-lymphoid red pulp and the lymphoid white-pulp of the spleen. A marginal zone also exists in lymph nodes.-Composition and markers:It is composed of cells derived...
.
There are three types:
- Splenic marginal zone lymphomaSplenic marginal zone lymphomaSplenic marginal zone lymphoma is a lymphoma made up of B-cells that replace the normal architecture of the white pulp of the spleen. The neoplastic cells are both small lymphocytes and larger, transformed blasts, and they invade the mantle zone of splenic follicles and erode the marginal zone,...
- Extranodal marginal zone B cell lymphoma (MALT lymphomaMALT lymphomaMALT lymphoma is a form of lymphoma involving the mucosa-associated lymphoid tissue , frequently of the stomach, but virtually any mucosal site can be afflicted...
, or "mucosa-associated lymphoid tissue") - Nodal marginal zone B cell lymphomaNodal marginal zone B cell lymphomaNodal marginal zone B cell lymphoma is a form of marginal-zone lymphoma that can produce colonization of the follicles....
(NMZL)
All three are CD5
CD5 (protein)
CD5 is a cluster of differentiation found on a subset of IgM-secreting B cells called B-1 cells, and also on T cells. B-1 cells have limited diversity of their B-cell receptor due to their lack of the enzyme terminal deoxynucleotidyl transferase and are potentially self-reactive...
and CD10 negative