Marshyhope Creek is a 37 miles (59.5 km) tributary

Tributary

A tributary or affluent is a stream or river that flows into a main stem river or a lake. A tributary does not flow directly into a sea or ocean...

 of the Nanticoke River

Nanticoke River

The Nanticoke River is a major tributary of the Chesapeake Bay on the Delmarva Peninsula. It rises in southern Kent County, Delaware, flows through Sussex County, Delaware, and forms the boundary between Dorchester County, Maryland and Wicomico County, Maryland. The river course proceeds southwest...

 on the Delmarva Peninsula

Delmarva Peninsula

The Delmarva Peninsula is a large peninsula on the East Coast of the United States, occupied by most of Delaware and portions of Maryland and Virginia...

. It rises in Kent County

Kent County, Delaware

Kent County is a county located in the central part of the U.S. state of Delaware. It is coextensive with the Dover, Delaware, Metropolitan Statistical Area. As of 2010 the population was 162,310, a 28.1% increase over the previous decade. The county seat is Dover, the state capital...

, Delaware

Delaware

Delaware is a U.S. state located on the Atlantic Coast in the Mid-Atlantic region of the United States. It is bordered to the south and west by Maryland, and to the north by Pennsylvania...

, and runs through Caroline County

Caroline County, Maryland

Caroline County is a wholly rural county located in the U.S. state of Maryland on its Eastern Shore. It is bordered by Queen Anne's County to the north, Talbot County to the west, Dorchester County to the south, Kent County, Delaware, to the east, and Sussex County, Delaware, to the southeast. As...

, Maryland

Maryland

Maryland is a U.S. state located in the Mid Atlantic region of the United States, bordering Virginia, West Virginia, and the District of Columbia to its south and west; Pennsylvania to its north; and Delaware to its east...

, and Dorchester County, Maryland

Dorchester County, Maryland

Dorchester County is a county located in the U.S. state of Maryland on its Eastern Shore. It is bordered by the Choptank River to the north, Talbot County to the northwest, Caroline County to the northeast, Wicomico County to the southeast, Sussex County, Delaware, to the east, and the Chesapeake...

.

Marshyhope Creek begins in southwestern Kent County, Delaware, near the city of Harrington

Harrington, Delaware

Harrington is a city in Kent County, Delaware, United States. It is part of the Dover, Delaware Metropolitan Statistical Area. Harrington hosts the annual Delaware State Fair each July...

, and ends at the Nanticoke River

Nanticoke River

The Nanticoke River is a major tributary of the Chesapeake Bay on the Delmarva Peninsula. It rises in southern Kent County, Delaware, flows through Sussex County, Delaware, and forms the boundary between Dorchester County, Maryland and Wicomico County, Maryland. The river course proceeds southwest...

, near Sharptown, Maryland

Sharptown, Maryland

Sharptown is a town in Wicomico County, Maryland, United States. The population was 649 at the 2000 census. It is included in the Salisbury, Maryland Metropolitan Statistical Area.-Geography:Sharptown is located at ....

. The entire watershed is in the coastal plain and reaches sea level at Brookview, Maryland

Brookview, Maryland

Brookview is a town in Dorchester County, Maryland, United States. The population was 65 at the 2000 census.-Geography:Brookview is located at ....

. Federalsburg

Federalsburg, Maryland

Federalsburg is a town in Caroline County, Maryland, United States. The population was 2,642 at the 2009 census. The ZIP code is 21632. The primary phone exchange is 754 and the area code is 410.-Town features:...

is the head of navigation.

There are several small creeks on the western shore, including Faulkner Branch, Sullivan Branch, Capital Branch, Green Branch, and Horsepen Arm. On the eastern shore the small creeks include Tanyard Branch, Houston Branch, Jones Mill Branch, Double Fork Branch, Quarter Branch, Tomahawk Branch, and Prospect Point Branch.