Route 141 is a west–east state highway

State highway

State highway, state road or state route can refer to one of three related concepts, two of them related to a state or provincial government in a country that is divided into states or provinces :#A...

 in the U.S. state

U.S. state

A U.S. state is any one of the 50 federated states of the United States of America that share sovereignty with the federal government. Because of this shared sovereignty, an American is a citizen both of the federal entity and of his or her state of domicile. Four states use the official title of...

 of Massachusetts

Massachusetts

The Commonwealth of Massachusetts is a state in the New England region of the northeastern United States of America. It is bordered by Rhode Island and Connecticut to the south, New York to the west, and Vermont and New Hampshire to the north; at its east lies the Atlantic Ocean. As of the 2010...

. Its western terminus is at Route 10

Massachusetts Route 10

Massachusetts Route 10 is a north–south state highway that runs from the state line at Southwick to the state line at Northfield.-Route description:Route 10 crosses the border from Granby, Connecticut into Southwick, Massachusetts, overlapped with US 202...

 in Easthampton

Easthampton, Massachusetts

Easthampton is the second largest city in Hampshire County, Massachusetts, United States. The town is on the southeastern edge of an area called the Pioneer Valley near the five colleges in the college towns of Northampton and Amherst, MA...

. Its eastern terminus is at U.S. Route 20

U.S. Route 20

U.S. Route 20 is an east–west United States highway. As the "0" in its route number implies, US 20 is a coast-to-coast route. Spanning , it is the longest road in the United States, and the route sparsely parallels Interstate 90...

 in Springfield

Springfield, Massachusetts

Springfield is the most populous city in Western New England, and the seat of Hampden County, Massachusetts, United States. Springfield sits on the eastern bank of the Connecticut River near its confluence with three rivers; the western Westfield River, the eastern Chicopee River, and the eastern...

 while concurrent with Route 21

Massachusetts Route 21

Route 21 is a south–north state highway in Massachusetts that runs between Springfield and Belchertown.-Route description:The route begins at U.S. Route 20 in the Indian Orchard section of Springfield. It heads north, intersecting with Route 141 before crossing the Chicopee River into...

.

An odd sight greeted motorists in Easthampton in July, 2005 on Route 10 at the western terminus of Route 141: standard issue Alabama state highway signs with the numbers 10 and 141 in a map of that state, instead of the standard Massachusetts square. This odd "Alabama 10" and "Alabama 141" signage came about when a contractor mistakenly applied the sample from a federal manual.