Matt Kaeberlein
Encyclopedia
Dr. Matt Kaeberlein is an American biologist and biogerontologist best known for his research on evolutionarily conserved mechanisms of aging. He is currently at the University of Washington
where he is a professor in the Department of Pathology.
While a graduate student in the laboratory of Leonard Guarente at the Massachusetts Institute of Technology
, he discovered that increased activity of the Sir2
enzyme increases lifespan in the budding yeast.
Along with Preston Estep
, Dr. Kaeberlein co-founded the human longevity research biotech company Longenity, Inc.
Dr. Kaeberlein was a post-doctoral fellow in the laboratory of Dr. Stanley Fields, where he carried out genome-wide screens for genes that regulate aging in yeast.
Along with Dr. Brian Kennedy
, Kaeberlein has vocally questioned the hypothesis that lifespan extension from caloric restriction is mediated by Sirtuins. Instead Kaeberlein and Kennedy have proposed that the caloric restriction increases lifespan by decreasing the activity of the Target of Rapamycin (TOR) kinase
.
University of Washington
University of Washington is a public research university, founded in 1861 in Seattle, Washington, United States. The UW is the largest university in the Northwest and the oldest public university on the West Coast. The university has three campuses, with its largest campus in the University...
where he is a professor in the Department of Pathology.
While a graduate student in the laboratory of Leonard Guarente at the Massachusetts Institute of Technology
Massachusetts Institute of Technology
The Massachusetts Institute of Technology is a private research university located in Cambridge, Massachusetts. MIT has five schools and one college, containing a total of 32 academic departments, with a strong emphasis on scientific and technological education and research.Founded in 1861 in...
, he discovered that increased activity of the Sir2
Sir2
Sir2 was the first gene of the sirtuin genes to be found. It was found in budding yeast, and, since then, members of this highly conserved family have been found in nearly all organisms studied...
enzyme increases lifespan in the budding yeast.
Along with Preston Estep
Preston Estep
Preston W. Estep III is an American biologist and science and technology advocate. He is a graduate of Cornell University, where he did neuroscience research, and he earned a Ph.D. in Genetics from Harvard University. He did his doctoral research in the laboratory of genomics pioneer Professor...
, Dr. Kaeberlein co-founded the human longevity research biotech company Longenity, Inc.
Dr. Kaeberlein was a post-doctoral fellow in the laboratory of Dr. Stanley Fields, where he carried out genome-wide screens for genes that regulate aging in yeast.
Along with Dr. Brian Kennedy
Brian K Kennedy
Brian K. Kennedy is an American biologist best known for his research on aging in yeast. Dr. Kennedy began his research in aging in the lab of Dr. Leonard at MIT....
, Kaeberlein has vocally questioned the hypothesis that lifespan extension from caloric restriction is mediated by Sirtuins. Instead Kaeberlein and Kennedy have proposed that the caloric restriction increases lifespan by decreasing the activity of the Target of Rapamycin (TOR) kinase
Mammalian target of rapamycin
The mammalian target of rapamycin also known as mechanistic target of rapamycin or FK506 binding protein 12-rapamycin associated protein 1 is a protein which in humans is encoded by the FRAP1 gene...
.