The Mayo brothers were Charles Horace Mayo

Charles Horace Mayo

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 and William James Mayo

William James Mayo

William James Mayo, M.D. was a physician in the United States and one of the seven founders of the Mayo Clinic. He and his brother, Charles Horace Mayo, both joined their father's private medical practice in Rochester, Minnesota, USA, after graduating from medical school in the 1880s...

, who with the help of their partners, co-founded the Mayo Clinic

Mayo Clinic

Mayo Clinic is a not-for-profit medical practice and medical research group specializing in treating difficult patients . Patients are referred to Mayo Clinic from across the U.S. and the world, and it is known for innovative and effective treatments. Mayo Clinic is known for being at the top of...

. The original partners in the practice were the Mayo brothers, Drs. Stinchfield, Judd, Graham, Plummer, Millet and Balfour. In 1919, the remaining partners in the private practice established the Mayo Properties Association and became a not-for-profit institution. The Mayo Clinic grew out of this private practice, which was originally started by the Mayo's father, William Worrall Mayo

William Worrall Mayo

William Worrall Mayo was a British medical doctor and chemist, best known for establishing the private medical practice that later evolved into the Mayo Clinic. He was a descendant of a famous English chemist, John Mayow. His sons, William James Mayo and Charles Horace Mayo, joined the private...

, in 1863 in Rochester, Minnesota, USA.