MeOPP
Encyclopedia
para-Methoxyphenylpiperazine (MeOPP, pMPP, 4-MPP; Paraperazine) is a piperazine
derivative with stimulant
effects which has been sold as an ingredient in "Party pills
", initially in New Zealand
and subsequently in other countries around the world.
MeOPP has been found in vitro to inhibit
the reuptake
and induce the release
of the monoamine neurotransmitter
s. This is a mechanism of action shared with drugs of abuse such as amphetamines, and MeOPP produces somewhat similar effects although it is much less potent and is thought to have relatively insignificant abuse potential. Piperazine derivatives such as trifluoromethylphenylpiperazine
(TFMPP) have also been shown to exert a major part of their mechanism of action as nonselective serotonin receptor agonist
s, and MeOPP has also been demonstrated to act in this way. MeOPP is anecdotally said to induce significantly less anxiety than similar piperazines, and is usually taken at doses between 120–200 mg. It does not produce prominent stimulant effects, but is instead said to be relaxing, however it is often mixed with stimulant piperazine derivatives such as benzylpiperazine
(BZP) for a combined effect.
Based on the recommendation of the EACD, the New Zealand government has passed legislation which placed BZP, along with a number of other piperazine derivatives into Class C of the New Zealand Misuse of Drugs Act 1975. A ban was intended to come into effect in New Zealand on December 18 2007, but the law change did not go through until the following year, and the sale of BZP and the other listed piperazines became illegal in New Zealand as of 1st of April 2008. An amnesty for possession and usage of these drugs remained until October 2008, at which point they became completely illegal.
Piperazine
Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. Piperazine exists as small alkaline deliquescent crystals with a saline taste....
derivative with stimulant
Stimulant
Stimulants are psychoactive drugs which induce temporary improvements in either mental or physical function or both. Examples of these kinds of effects may include enhanced alertness, wakefulness, and locomotion, among others...
effects which has been sold as an ingredient in "Party pills
Party pills
Party pills, also known as "herbal highs", "pep pills" "dance pills" and "natural power", is a colloquialism for a type of recreational drug whose main ingredient was originally benzylpiperazine , but has now expanded to a wide range of compounds with a variety of effects...
", initially in New Zealand
New Zealand
New Zealand is an island country in the south-western Pacific Ocean comprising two main landmasses and numerous smaller islands. The country is situated some east of Australia across the Tasman Sea, and roughly south of the Pacific island nations of New Caledonia, Fiji, and Tonga...
and subsequently in other countries around the world.
MeOPP has been found in vitro to inhibit
Reuptake inhibitor
A reuptake inhibitor , also known as a transporter blocker, is a drug that inhibits the plasmalemmal transporter-mediated reuptake of a neurotransmitter from the synapse into the pre-synaptic neuron, leading to an increase in the extracellular concentrations of the neurotransmitter and therefore an...
the reuptake
Reuptake
Reuptake, or re-uptake, is the reabsorption of a neurotransmitter by a neurotransmitter transporter of a pre-synaptic neuron after it has performed its function of transmitting a neural impulse....
and induce the release
Releasing agent
A releasing agent , or simply releaser, is a drug that induces the release of a neurotransmitter from the presynaptic neuron into the synapse, leading to an increase in the extracellular concentrations of the neurotransmitter. Many drugs use neurotransmitter release to exert their psychological and...
of the monoamine neurotransmitter
Neurotransmitter
Neurotransmitters are endogenous chemicals that transmit signals from a neuron to a target cell across a synapse. Neurotransmitters are packaged into synaptic vesicles clustered beneath the membrane on the presynaptic side of a synapse, and are released into the synaptic cleft, where they bind to...
s. This is a mechanism of action shared with drugs of abuse such as amphetamines, and MeOPP produces somewhat similar effects although it is much less potent and is thought to have relatively insignificant abuse potential. Piperazine derivatives such as trifluoromethylphenylpiperazine
Trifluoromethylphenylpiperazine
3-Trifluoromethylphenylpiperazine is a recreational drug of the piperazine chemical class. Usually in combination with its analogue benzylpiperazine , it is sold as a legal alternative to the illicit drug MDMA under the name "Legal X".- Pharmacology :TFMPP has affinity for the 5-HT1A , 5-HT1B ,...
(TFMPP) have also been shown to exert a major part of their mechanism of action as nonselective serotonin receptor agonist
Serotonin receptor agonist
A serotonin receptor agonist is a compound that activates serotonin receptors, mimicking the effect of the neurotransmitter serotonin. There are various serotonin receptors and ligands.-5-HT1A receptor:...
s, and MeOPP has also been demonstrated to act in this way. MeOPP is anecdotally said to induce significantly less anxiety than similar piperazines, and is usually taken at doses between 120–200 mg. It does not produce prominent stimulant effects, but is instead said to be relaxing, however it is often mixed with stimulant piperazine derivatives such as benzylpiperazine
Benzylpiperazine
Benzylpiperazine is a recreational drug with euphoric, stimulant properties. The effects produced by BZP are comparable to those produced by amphetamine. Adverse effects have been reported following its use including acute psychosis, renal toxicity, and seizures...
(BZP) for a combined effect.
Based on the recommendation of the EACD, the New Zealand government has passed legislation which placed BZP, along with a number of other piperazine derivatives into Class C of the New Zealand Misuse of Drugs Act 1975. A ban was intended to come into effect in New Zealand on December 18 2007, but the law change did not go through until the following year, and the sale of BZP and the other listed piperazines became illegal in New Zealand as of 1st of April 2008. An amnesty for possession and usage of these drugs remained until October 2008, at which point they became completely illegal.
See also
- 1-Benzylpiperazine (BZP)
- 1-Methyl-4-benzylpiperazine1-Methyl-4-benzylpiperazineMBZP is a stimulant drug which is a derivative of benzylpiperazine. MBZP has been sold as an ingredient in legal recreational drugs known as "Party pills", initially in New Zealand and subsequently in other countries around the world.The effects of MBZP are very similar to those of BZP, but the...
(MBZP) - 1,4-Dibenzylpiperazine (DBZP)
- 3-Chlorophenylpiperazine1-(3-Chlorophenyl)piperazinemeta-Chlorophenylpiperazine is a psychoactive drug of the phenylpiperazine class. It was initially developed in the late-1970s and used in scientific research before being sold as a designer drug in the mid-2000s...
(mCPP) - 3-Trifluoromethylphenylpiperazine (TFMPP)
- 3,4-Methylenedioxy-1-benzylpiperazine (MDBZP)
- 4-Bromo-2,5-dimethoxy-1-benzylpiperazine (2C-B-BZP)
- 4-FluorophenylpiperazinePFPPpara-Fluorophenylpiperazine is a piperazine derivative with mildly psychedelic and euphoriant effects...
(pFPP)