Mean platelet volume
Encyclopedia
Mean platelet volume is a machine-calculated measurement of the average size of platelets found in blood
and is typically included in blood tests as part of the CBC
. Since the average platelet size is larger when the body is producing increased numbers of platelets the MPV test results can be used to make inferences about platelet production in bone marrow
or platelet destruction problems.Page text.
MPV is higher when there is destruction to platelets. This may be seen as in immune thrombocytopenic purpura (ITP), and in myeloproliferative disease
s and Bernard-Soulier syndrome
. It may also be related to Pre-eclampsia, and recovery from transient hypoplasia.
Abnormally low MPV values correlate primarily with thrombocytopenia
when it is due to impaired production as in aplastic anemia
. You may want to research megakaryocyte
if you are looking into causes and related information for a low mpv.
A typical range of platelet volumes is 9.7–12.8 fL (femtolitre
), equivalent to spheres 2.65 to 2.9 µm
in diameter.
Normal Range is given as 7.5-11.5 FL
Blood
Blood is a specialized bodily fluid in animals that delivers necessary substances such as nutrients and oxygen to the cells and transports metabolic waste products away from those same cells....
and is typically included in blood tests as part of the CBC
Complete blood count
A complete blood count , also known as full blood count or full blood exam or blood panel, is a test panel requested by a doctor or other medical professional that gives information about the cells in a patient's blood...
. Since the average platelet size is larger when the body is producing increased numbers of platelets the MPV test results can be used to make inferences about platelet production in bone marrow
Bone marrow
Bone marrow is the flexible tissue found in the interior of bones. In humans, bone marrow in large bones produces new blood cells. On average, bone marrow constitutes 4% of the total body mass of humans; in adults weighing 65 kg , bone marrow accounts for approximately 2.6 kg...
or platelet destruction problems.Page text.
MPV is higher when there is destruction to platelets. This may be seen as in immune thrombocytopenic purpura (ITP), and in myeloproliferative disease
Myeloproliferative disease
The myeloproliferative diseases are a group of diseases of the bone marrow in which excess cells are produced. They are related to, and may evolve into, myelodysplastic syndrome and acute myeloid leukemia, although the myeloproliferative diseases on the whole have a much better prognosis than...
s and Bernard-Soulier syndrome
Bernard-Soulier syndrome
Bernard–Soulier syndrome , also called hemorrhagiparous thrombocytic dystrophy, is a rare autosomal recessive coagulopathy that causes a deficiency of glycoprotein Ib , the receptor for von Willebrand factor, which is important in clot formation.The incidence is estimated to be less than 1 in 1...
. It may also be related to Pre-eclampsia, and recovery from transient hypoplasia.
Abnormally low MPV values correlate primarily with thrombocytopenia
Thrombocytopenia
Thrombocytopenia is a relative decrease of platelets in blood.A normal human platelet count ranges from 150,000 to 450,000 platelets per microliter of blood. These limits are determined by the 2.5th lower and upper percentile, so values outside this range do not necessarily indicate disease...
when it is due to impaired production as in aplastic anemia
Aplastic anemia
Aplastic anemia is a condition where bone marrow does not produce sufficient new cells to replenish blood cells. The condition, per its name, involves both aplasia and anemia...
. You may want to research megakaryocyte
Megakaryocyte
The megakaryocyte is a bone marrow cell responsible for the production of blood thrombocytes , which are necessary for normal blood clotting...
if you are looking into causes and related information for a low mpv.
A typical range of platelet volumes is 9.7–12.8 fL (femtolitre
Femtolitre
The femto litre is the metric unit of volume equal to 10−15 litre, or one quinine cillionth or one quadrillionth litre. It is abbreviated FL or fl. One femto litre is the same as 1 μm3.1....
), equivalent to spheres 2.65 to 2.9 µm
Micrometre
A micrometer , is by definition 1×10-6 of a meter .In plain English, it means one-millionth of a meter . Its unit symbol in the International System of Units is μm...
in diameter.
Normal Range is given as 7.5-11.5 FL
External links
- MPV Definition
- http://www.medicinenet.com/thrombocytopenia_low_platelet_count/page4.htm Medicinenet.com: Thrombocytopenia
- http://www.diabetesexplained.com/mean-platelet-volume.html Diabetesexplained.com: MPV
- http://atvb.ahajournals.org/cgi/content/short/ATVBAHA.110.221788v1 ahajournals.org: Article related to MPV
- http://www.ncbi.nlm.nih.gov/pubmed/4074887: NIH.gov: article related to MPV
- http://www.wisegeek.com/what-is-mean-platelet-volume.htm Wisegeekcom: What is Mean Platelet Volume
- http://www.clinlabnavigator.com/Test-Interpretations/mean-platelet-volume.html?letter=M Clinlabnavigator.com: MPV