Melanin-concentrating hormone receptor 1
Encyclopedia
Melanin-concentrating hormone receptor 1, also known as MCH1, is one of the human melanin-concentrating hormone receptor
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Melanin-concentrating hormone receptor
Two Melanin-concentrating hormone receptors have recently been characterized: MCH-R1 and MCH-R2. These two receptors share approximately 38% homology.* MCH-R1 is expressed in all mammals....
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Function
MCH1 is thought to have a number of functions including in the regulation of appetite, and in stress, anxiety and depression.Agonists
- Melanin concentrating hormoneMelanin concentrating hormoneMelanin-concentrating hormone is a cyclic 19-amino acid orexinogenic hypothalamic peptide originally isolated from the pituitary gland of teleost fish where it controls skin pigmentation....
(MCH) - S-36057 - modified MCH 6-13 fragment substituted with 3-iodotyrosine at N-terminus via dioxyoctanoyl linker, used as 125I radioligandIsotopic labelingIsotopic labeling is a technique for tracking the passage of a sample of substance through a system. The substance is 'labeled' by including unusual isotopes in its chemical composition...
for mapping MCH1 in vivo.
Antagonists
- ATC-0065
- ATC-0175ATC-0175ATC-0175 is a drug used in scientific research, which is a selective, non-peptide antagonist at the melanin concentrating hormone receptor MCH1. In animal studies it has been shown to produce both anxiolytic and antidepressant actions, but without sedative or ataxic side effects....
- GW-803,430GW-803,430GW-803,430 is a drug used in scientific research and is a selective non-peptide antagonist at the melanin concentrating hormone receptor MCH1. In animal studies it has anxiolytic, antidepressant and anorectic effects.- References :...
- NGD-4715NGD-4715NGD-4715 is a drug developed by Neurogen, which acts as a selective, non-peptide antagonist at the melanin concentrating hormone receptor MCH1...
- SNAP-7941SNAP-7941SNAP-7941 is a drug used in scientific research, which is a selective, non-peptide antagonist at the melanin concentrating hormone receptor MCH1...
- SNAP-94847SNAP-94847SNAP-94847 is a drug used in scientific research, which is a selective, non-peptide antagonist at the melanin concentrating hormone receptor MCH1. In animal studies it has been shown to produce both anxiolytic and antidepressant effects, and also reduces food consumption suggesting a possible...
- T-226,296