Melanin-concentrating hormone receptor 2
Encyclopedia
Melanin-concentrating hormone receptor 2 (MCH2) also known as G-protein coupled receptor 145 (GPR145) is a protein
that in humans is encoded by the MCHR2 gene
.
MCH2 is also found in dogs, ferrets, and some other primates and carnivores, but is not found in mice or rats. This has delayed research into the receptor as a therapeutic target, due to most early pharmaceutical research usually being conducted in small mammals such as mice, rats or rabbits which lack the MCH2 gene and its receptor product.
resulted in upregulation of IDH3A
, PCK1
and PFKFB4
and the downregulation of INSIG2
and ACOT8
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the MCHR2 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
MCH2 is also found in dogs, ferrets, and some other primates and carnivores, but is not found in mice or rats. This has delayed research into the receptor as a therapeutic target, due to most early pharmaceutical research usually being conducted in small mammals such as mice, rats or rabbits which lack the MCH2 gene and its receptor product.
Clinical Significance
Treatment of human cells expressing MCHR2 with MCHMelanin concentrating hormone
Melanin-concentrating hormone is a cyclic 19-amino acid orexinogenic hypothalamic peptide originally isolated from the pituitary gland of teleost fish where it controls skin pigmentation....
resulted in upregulation of IDH3A
IDH3A
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial is an enzyme that in humans is encoded by the IDH3A gene.- Interactive pathway map :-Further reading:...
, PCK1
PCK1
Phosphoenolpyruvate carboxykinase 1 , also known as PCK1, is an enzyme which in humans is encoded by the PCK1 gene.- Function:This enzyme is a main control point for the regulation of gluconeogenesis...
and PFKFB4
PFKFB4
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 also known as PFKFB4 is a enzyme which in humans is encoded by the PFKFB4 gene.- Function :...
and the downregulation of INSIG2
INSIG2
Insulin induced gene 2, also known as INSIG2, is a protein which in humans is encoded by the INSIG2 gene.- Regulation :Insulin activates the human INSIG2 promoter in a process mediated by phosphorylated SAP1a....
and ACOT8
ACOT8
Acyl-coenzyme A thioesterase 8 is an enzyme that in humans is encoded by the ACOT8 gene.-Further reading:...
.