Methylmagnesium chloride
Encyclopedia
Methylmagnesium chloride is a commercially available Grignard reagent. Like methyllithium, it is the synthetic equivalent to the methyl carbanion synthon
. It is usually sold as a solution in tetrahydrofuran
. The model of the molecule shows methylmagnesium chloride with the magnesium atom in the center. Two molecules of tetrahydrofuran
(in the upper part of the drawing) coordinate by their oxygen atoms to magnesium.
Like all Grignard reagents, this is a moisture sensitive compound.
Synthon
A synthon is a concept in retrosynthetic analysis. It is defined as a structural unit within a molecule which is related to a possible synthetic operation. The term was coined by E.J. Corey...
. It is usually sold as a solution in tetrahydrofuran
Tetrahydrofuran
Tetrahydrofuran is a colorless, water-miscible organic liquid with low viscosity at standard temperature and pressure. This heterocyclic compound has the chemical formula 4O. As one of the most polar ethers with a wide liquid range, it is a useful solvent. Its main use, however, is as a precursor...
. The model of the molecule shows methylmagnesium chloride with the magnesium atom in the center. Two molecules of tetrahydrofuran
Tetrahydrofuran
Tetrahydrofuran is a colorless, water-miscible organic liquid with low viscosity at standard temperature and pressure. This heterocyclic compound has the chemical formula 4O. As one of the most polar ethers with a wide liquid range, it is a useful solvent. Its main use, however, is as a precursor...
(in the upper part of the drawing) coordinate by their oxygen atoms to magnesium.
Like all Grignard reagents, this is a moisture sensitive compound.