Milan criteria
Encyclopedia
In transplantation medicine, the Milan criteria are applied as a basis for selecting patients with cirrhosis
and hepatocellular carcinoma
for liver transplantation
.
The Milan criteria state that a patient is selected for transplantation when he or she has:
Cirrhosis
Cirrhosis is a consequence of chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue and regenerative nodules , leading to loss of liver function...
and hepatocellular carcinoma
Hepatocellular carcinoma
Hepatocellular carcinoma is the most common type of liver cancer. Most cases of HCC are secondary to either a viral hepatitide infection or cirrhosis .Compared to other cancers, HCC is quite a rare tumor in the United States...
for liver transplantation
Liver transplantation
Liver transplantation or hepatic transplantation is the replacement of a diseased liver with a healthy liver allograft. The most commonly used technique is orthotopic transplantation, in which the native liver is removed and replaced by the donor organ in the same anatomic location as the original...
.
The Milan criteria state that a patient is selected for transplantation when he or she has:
- one lesion smaller than 5cm.
- up to 3 lesions smaller than 3 cm.
- no extrahepatic manifestations
- no vascular invasion