Molecular assembler
Encyclopedia
A molecular assembler, as defined by K. Eric Drexler
K. Eric Drexler
Dr. Kim Eric Drexler is an American engineer best known for popularizing the potential of molecular nanotechnology , from the 1970s and 1980s.His 1991 doctoral thesis at MIT was revised and published as...

, is a "proposed device able to guide chemical reactions by positioning reactive molecules with atomic precision". Some biological molecules such as ribosome
Ribosome
A ribosome is a component of cells that assembles the twenty specific amino acid molecules to form the particular protein molecule determined by the nucleotide sequence of an RNA molecule....

s fit this definition. This is because they receive instructions from messenger RNA and then assemble specific sequences of amino acids to construct protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 molecules. However, the term "molecular assembler" usually refers to theoretical human-made devices.

Beginning in 2007, the British Engineering and Physical Sciences Research Council
Engineering and Physical Sciences Research Council
The Engineering and Physical Sciences Research Council is a British Research Council that provides government funding for grants to undertake research and postgraduate degrees in engineering and the physical sciences , mainly to universities in the United Kingdom...

 funds development of ribosome-like molecular assemblers. Clearly, molecular assemblers are possible in this limited sense. A technology roadmap project, led by the Battelle Memorial Institute
Battelle Memorial Institute
Battelle Memorial Institute is a private nonprofit applied science and technology development company headquartered in Columbus, Ohio. Battelle is a charitable trust organized as a nonprofit corporation under the laws of the State of Ohio and is exempt from taxation under Section 501 of the...

 and hosted by several U.S. National Laboratories
United States Department of Energy National Laboratories
The United States Department of Energy National Laboratories and Technology Centers are a system of facilities and laboratories overseen by the United States Department of Energy for the purpose of advancing science and helping promote the economic and defensive national interests of the United...

 has explored a range of atomically precise fabrication technologies, including both early-generation and longer-term prospects for programmable molecular assembly; the report was released in December, 2007. In 2008 the Engineering and Physical Sciences Research Council
Engineering and Physical Sciences Research Council
The Engineering and Physical Sciences Research Council is a British Research Council that provides government funding for grants to undertake research and postgraduate degrees in engineering and the physical sciences , mainly to universities in the United Kingdom...

 provided funding of 1.5 million pounds over six years for research working towards mechanized mechanosynthesis, in partnership with the Institute for Molecular Manufacturing, amongst others. http://gow.epsrc.ac.uk/ViewGrant.aspx?GrantRef=EP/G007837/1

Likewise, the term "molecular assembler" has been used in science fiction and popular culture to refer to a wide range of fantastic atom-manipulating nanomachines, many of which may be physically impossible in reality. Much of the controversy regarding "molecular assemblers" results from the confusion in the use of the name for both technical concepts and popular fantasies. In 1992, Drexler introduced the related but better-understood term "molecular manufacturing," which he defined as the programmed "chemical synthesis of complex structures by mechanically positioning reactive molecules
Mechanosynthesis
Mechanosynthesis is any chemical synthesis in which reaction outcomes are determined by the use of mechanical constraints to direct reactive molecules to specific molecular sites.-Introduction:...

, not by manipulating individual atoms."

This article mostly discusses "molecular assemblers" in the popular sense. These include hypothetical machines that manipulate individual atoms and machines with organism-like self-replicating abilities, mobility, ability to consume food, and so forth. These are quite different from devices that merely (as defined above) "guide chemical reactions by positioning reactive molecules with atomic precision".

Because synthetic molecular assemblers have never been constructed and because of the confusion regarding the meaning of the term, there has been much controversy as to whether "molecular assemblers" are possible or simply science fiction
Science fiction
Science fiction is a genre of fiction dealing with imaginary but more or less plausible content such as future settings, futuristic science and technology, space travel, aliens, and paranormal abilities...

. Confusion and controversy also stem from their classification as nanotechnology
Nanotechnology
Nanotechnology is the study of manipulating matter on an atomic and molecular scale. Generally, nanotechnology deals with developing materials, devices, or other structures possessing at least one dimension sized from 1 to 100 nanometres...

, which is an active area of laboratory research which has already been applied to the production of real products; however, there had been, until recently, no research efforts into the actual construction of "molecular assemblers". A primary criticism of the computational research into products of advanced "molecular assemblers" is that the structures investigated are impossible to make today.

Nanofactories

A nanofactory is a proposed system in which nanomachines
Nanotechnology
Nanotechnology is the study of manipulating matter on an atomic and molecular scale. Generally, nanotechnology deals with developing materials, devices, or other structures possessing at least one dimension sized from 1 to 100 nanometres...

 (resembling molecular assemblers, or industrial robot arms) would combine reactive molecules via mechanosynthesis
Mechanosynthesis
Mechanosynthesis is any chemical synthesis in which reaction outcomes are determined by the use of mechanical constraints to direct reactive molecules to specific molecular sites.-Introduction:...

 to build larger atomically precise parts. These, in turn, would be assembled by positioning mechanisms of assorted sizes to build macroscopic (visible) but still atomically-precise products.

A typical nanofactory would fit in a desktop box, in the vision of K. Eric Drexler
K. Eric Drexler
Dr. Kim Eric Drexler is an American engineer best known for popularizing the potential of molecular nanotechnology , from the 1970s and 1980s.His 1991 doctoral thesis at MIT was revised and published as...

 published in Nanosystems: Molecular Machinery, Manufacturing and Computation (1992), a notable work of "exploratory engineering
Exploratory engineering
Exploratory engineering is a term coined by K. Eric Drexler to describe the process of designing and analyzing detailed hypothetical models of systems that are not feasible with current technologies or methods, but do seem to be clearly within the bounds of what science considers to be possible...

". During the last decade, others have extended the nanofactory concept, including an analysis of nanofactory convergent assembly by Ralph Merkle
Ralph Merkle
Ralph C. Merkle is a researcher in public key cryptography, and more recently a researcher and speaker on molecular nanotechnology and cryonics...

, a systems design of a replicating nanofactory architecture by J. Storrs Hall
J. Storrs Hall
John Storrs Hall is involved in the field of molecular nanotechnology. He founded the sci.nanotech Usenet newsgroup and moderated it for ten years, and served as the founding chief scientist of Nanorex Inc. for two years...

, Forrest Bishop's "Universal Assembler", the patented exponential assembly process by Zyvex
Zyvex
Zyvex was the first molecular nanotechnology company, founded by James R. Von Ehr II in 1997.In April 2007, the corporation split into four components: Zyvex Technologies, Zyvex Instruments , Zyvex Labs, and Zyvex Asia....

, and a top-level systems design for a 'primitive nanofactory' by Chris Phoenix (Director of Research at the Center for Responsible Nanotechnology). All of these nanofactory designs (and more) are summarized in Chapter 4 of Kinematic Self-Replicating Machines (2004) by Robert Freitas
Robert Freitas
Robert A. Freitas Jr. is a Senior Research Fellow, one of four researchers at the nonprofit foundation Institute for Molecular Manufacturing in Palo Alto, California. He holds a 1974 Bachelor's degree majoring in both physics and psychology from Harvey Mudd College, and a 1978 Juris Doctor degree...

 and Ralph Merkle. The Nanofactory Collaboration, founded by Freitas and Merkle in 2000, is a focused ongoing effort involving 23 researchers from 10 organizations and 4 countries that is developing a practical research agenda specifically aimed at positionally-controlled diamond mechanosynthesis and diamondoid nanofactory development.

In 2005, a computer-animated short film of the nanofactory concept was produced by John Burch, in collaboration with Drexler. Such visions have been the subject of much debate, on several intellectual levels. No one has discovered an insurmountable problem with the underlying theories and no one has proved that the theories can be translated into practice. However, the debate continues, with some of it being summarized in the Molecular nanotechnology
Molecular nanotechnology
Molecular nanotechnology is a technology based on the ability to build structures to complex, atomic specifications by means of mechanosynthesis. This is distinct from nanoscale materials...

 article.

If nanofactories could be built, severe disruption to the world economy would be one of many possible negative impacts, though it could be argued that this disruption would have little negative effect if everyone had such nanofactories. Great benefits also would be anticipated. Various works of science fiction
Science fiction
Science fiction is a genre of fiction dealing with imaginary but more or less plausible content such as future settings, futuristic science and technology, space travel, aliens, and paranormal abilities...

 have explored these and similar concepts. The potential for such devices was part of the mandate of a major UK
United Kingdom
The United Kingdom of Great Britain and Northern IrelandIn the United Kingdom and Dependencies, other languages have been officially recognised as legitimate autochthonous languages under the European Charter for Regional or Minority Languages...

 study led by mechanical engineering
Mechanical engineering
Mechanical engineering is a discipline of engineering that applies the principles of physics and materials science for analysis, design, manufacturing, and maintenance of mechanical systems. It is the branch of engineering that involves the production and usage of heat and mechanical power for the...

 professor Dame Ann Dowling. The report is now complete.

Self-replication

"Molecular assemblers" have been confused with self-replicating machines. To produce a practical quantity of a desired product, the nanoscale size of a typical science fiction universal molecular assembler requires an extremely large number of such devices. However, a single such theoretical molecular assembler might be programmed to self-replicate, constructing many copies of itself. This would allow an exponential rate of production. Then after sufficient quantities of the molecular assemblers were available, they would then be re-programmed for production of the desired product. However, if self-replication of molecular assemblers were not restrained then it might lead to competition with naturally occurring organisms. This has been called ecophagy
Ecophagy
Ecophagy is a term coined by Robert Freitas that means the literal consuming of an ecosystem. It derives from the Greek "οικος" or Late Latin "oeco-", which refers to a "house" or "household", and Greek φᾰγεῖν phagein "to eat"...

 or the grey goo
Grey goo
Grey goo is a hypothetical end-of-the-world scenario involving molecular nanotechnology in which out-of-control self-replicating robots consume all matter on Earth while building more of themselves, a scenario known as ecophagy .Self-replicating machines of the macroscopic variety were originally...

 problem.

One method to building molecular assemblers is to mimic evolutionary processes employed by biological systems. Biological evolution proceeds by random variation combined with culling of the less-successful variants and reproduction of the more-successful variants. Production of complex molecular assemblers might be evolved from simpler systems since "A complex system that works is invariably found to have evolved from a simple system that worked. . . . A complex system designed from scratch never works and can not be patched up to make it work. You have to start over, beginning with a system that works." However, most published safety guidelines include
"recommendations against developing ... replicator designs which permit surviving mutation or undergoing evolution".

Most assembler designs keep the "source code" external to the physical assembler. At each step of a manufacturing process, that step is read from an ordinary computer file and "broadcast" to all the assemblers.
If any assembler gets out of range of that computer, or when the link between that computer and the assemblers is broken, or when that computer is unplugged, the assemblers stop replicating.
Such a "broadcast architecture" is one of the safety features recommended by the "Foresight Guidelines on Molecular Nanotechnology", and a map of the 137-dimensional replicator design space recently published by Freitas and Merkle provides numerous practical methods by which replicators can be safely controlled by good design.

Drexler and Smalley debate

One of the most outspoken critics of some concepts of "molecular assemblers" was Professor Richard Smalley
Richard Smalley
Richard Errett Smalley was the Gene and Norman Hackerman Professor of Chemistry and a Professor of Physics and Astronomy at Rice University, in Houston, Texas...

 (1943–2005) who won the Nobel prize
Nobel Prize
The Nobel Prizes are annual international awards bestowed by Scandinavian committees in recognition of cultural and scientific advances. The will of the Swedish chemist Alfred Nobel, the inventor of dynamite, established the prizes in 1895...

 for his contributions to the field of nanotechnology
Nanotechnology
Nanotechnology is the study of manipulating matter on an atomic and molecular scale. Generally, nanotechnology deals with developing materials, devices, or other structures possessing at least one dimension sized from 1 to 100 nanometres...

. Smalley believed that such assemblers were not physically possible and introduced scientific objections to them. His two principal technical objections were termed the "fat fingers problem" and the "sticky fingers problem". He believed these would exclude the possibility of "molecular assemblers" that worked by precision picking and placing of individual atoms. Drexler and coworkers responded to these two issues in a 2001 publication.

Smalley also believed that Drexler's speculations about apocalyptic dangers of self-replicating machines that have been equated with "molecular assemblers" would threaten the public support for development of nanotechnology. To address the debate between Drexler and Smalley regarding molecular assemblers Chemical & Engineering News
Chemical & Engineering News
Chemical & Engineering News is a weekly magazine published by the American Chemical Society, providing professional and technical information in the fields of chemistry and chemical engineering...

published a point-counterpoint consisting of an exchange of letters that addressed the issues.

Regulation

Speculation on the power of systems that have been called "molecular assemblers" has sparked a wider political discussion on the implication of nanotechnology. This is in part due to the fact that nanotechnology is a very broad term and could include "molecular assemblers." Discussion of the possible implications of fantastic molecular assemblers has prompted calls for regulation of current and future nanotechnology. There are very real concerns with the potential health and ecological impact of nanotechnology that is being integrated in manufactured products. Greenpeace
Greenpeace
Greenpeace is a non-governmental environmental organization with offices in over forty countries and with an international coordinating body in Amsterdam, The Netherlands...

 for instance commissioned a report concerning nanotechnology in which they express concern into the toxicity of nanomaterials that have been introduced in the environment. However, it makes only passing references to "assembler" technology. The UK Royal Society
Royal Society
The Royal Society of London for Improving Natural Knowledge, known simply as the Royal Society, is a learned society for science, and is possibly the oldest such society in existence. Founded in November 1660, it was granted a Royal Charter by King Charles II as the "Royal Society of London"...

 and UK Royal Academy of Engineering
Royal Academy of Engineering
-Overview: is the UK’s national academy of engineering. The Academy brings together the most successful and talented engineers from across the engineering sectors for a shared purpose: to advance and promote excellence in engineering....

 also commissioned a report entitled "Nanoscience and nanotechnologies: opportunities and uncertainties" regarding the larger social and ecological implications on nanotechnology. This report does not discuss the threat posed by potential so-called "molecular assemblers."

Formal scientific review

In 2006, U.S. National Academy of Sciences released the report of a study of molecular manufacturing as part of a longer report, A Matter of Size: Triennial Review of the National Nanotechnology Initiative The study committee reviewed the technical content of Nanosystems, and in its conclusion states that no current theoretical analysis can be considered definitive regarding several questions of potential system performance, and that optimal paths for implementing high-performance systems cannot be predicted with confidence. It recommends experimental research to advance knowledge in this area:
"Although theoretical calculations can be made today, the eventually attainable range of chemical reaction cycles, error rates, speed of operation, and thermodynamic efficiencies of such bottom-up manufacturing systems cannot be reliably predicted at this time. Thus, the eventually attainable perfection and complexity of manufactured products, while they can be calculated in theory, cannot be predicted with confidence. Finally, the optimum research paths that might lead to systems which greatly exceed the thermodynamic efficiencies and other capabilities of biological systems cannot be reliably predicted at this time. Research funding that is based on the ability of investigators to produce experimental demonstrations that link to abstract models and guide long-term vision is most appropriate to achieve this goal."

Grey goo

One potential scenario that has been envisioned is out-of-control self-replicating molecular assemblers in the form of grey goo
Grey goo
Grey goo is a hypothetical end-of-the-world scenario involving molecular nanotechnology in which out-of-control self-replicating robots consume all matter on Earth while building more of themselves, a scenario known as ecophagy .Self-replicating machines of the macroscopic variety were originally...

 which consumes carbon to continue its replication. If unchecked such mechanical replication could potentially consume whole ecoregion
Ecoregion
An ecoregion , sometimes called a bioregion, is an ecologically and geographically defined area that is smaller than an ecozone and larger than an ecosystem. Ecoregions cover relatively large areas of land or water, and contain characteristic, geographically distinct assemblages of natural...

s or the whole Earth (ecophagy
Ecophagy
Ecophagy is a term coined by Robert Freitas that means the literal consuming of an ecosystem. It derives from the Greek "οικος" or Late Latin "oeco-", which refers to a "house" or "household", and Greek φᾰγεῖν phagein "to eat"...

), or it could simply outcompete natural lifeforms for necessary resources such as carbon
Carbon
Carbon is the chemical element with symbol C and atomic number 6. As a member of group 14 on the periodic table, it is nonmetallic and tetravalent—making four electrons available to form covalent chemical bonds...

, ATP
Adenosine triphosphate
Adenosine-5'-triphosphate is a multifunctional nucleoside triphosphate used in cells as a coenzyme. It is often called the "molecular unit of currency" of intracellular energy transfer. ATP transports chemical energy within cells for metabolism...

, or UV light (which some nanomotor
Nanomotor
A nanomotor is a molecular device capable of converting energy into movement. It can typically generate forces on the order of piconewtons.A proposed branch of research is the integration of molecular motor proteins found in living cells into molecular motors implanted in artificial devices...

 examples run on). It is worth noting that the ecophagy
Ecophagy
Ecophagy is a term coined by Robert Freitas that means the literal consuming of an ecosystem. It derives from the Greek "οικος" or Late Latin "oeco-", which refers to a "house" or "household", and Greek φᾰγεῖν phagein "to eat"...

 and 'grey goo' scenarios, like synthetic molecular assemblers, are based upon still-theoretical technologies that have not yet been demonstrated experimentally.

In fiction

Molecular assemblers are a popular topic in science fiction, for example, the matter compiler in The Diamond Age and the cornucopia machine in Singularity Sky
Singularity Sky
- External links :* at * * at Worlds Without End...

. The replicator
Replicator (Star Trek)
In Star Trek a replicator is a machine capable of creating objects. Replicators were originally seen used to synthesize meals on demand, but in later series they took on many other uses.-Origins and limitations:...

 in Star Trek
Star Trek
Star Trek is an American science fiction entertainment franchise created by Gene Roddenberry. The core of Star Trek is its six television series: The Original Series, The Animated Series, The Next Generation, Deep Space Nine, Voyager, and Enterprise...

 might also be considered a molecular assembler. A molecular assembler is also a key element of the plot of the computer game Deus Ex
Deus Ex
Deus Ex is an action role-playing game developed by Ion Storm Inc. and published by Eidos Interactive in 2000, which combines gameplay elements of first-person shooters with those of role-playing video games...

(called a "universal constructor
Universal constructor
A universal constructor may refer to*Universal assembler, a hypothesized nanotechnology device for building a large class of nanomachines including itself, or...

" in the game).

See also

  • Nanotechnology
    Nanotechnology
    Nanotechnology is the study of manipulating matter on an atomic and molecular scale. Generally, nanotechnology deals with developing materials, devices, or other structures possessing at least one dimension sized from 1 to 100 nanometres...

  • Molecular machine
    Molecular machine
    A molecular machine, or nanomachine, is any discrete number of molecular components that produce quasi-mechanical movements in response to specific stimuli . The expression is often more generally applied to molecules that simply mimic functions that occur at the macroscopic level...

  • Bioethics
    Bioethics
    Bioethics is the study of controversial ethics brought about by advances in biology and medicine. Bioethicists are concerned with the ethical questions that arise in the relationships among life sciences, biotechnology, medicine, politics, law, and philosophy....

  • Biosafety
    Biosafety
    Biosafety: prevention of large-scale loss of biological integrity, focusing both on ecology and human health .Biosafety is related to several fields:*In ecology ,...

  • Biosecurity
    Biosecurity
    Biosecurity is a set of preventive measures designed to reduce the risk of transmission of infectious diseases, quarantined pests, invasive alien species, living modified organisms...

  • Biotechnology
    Biotechnology
    Biotechnology is a field of applied biology that involves the use of living organisms and bioprocesses in engineering, technology, medicine and other fields requiring bioproducts. Biotechnology also utilizes these products for manufacturing purpose...

  • Ecocide
    Ecocide
    The neologism ecocide can be used to refer to any large-scale destruction of the natural environment or over-consumption of critical non-renewable resources...

  • Ecophagy
    Ecophagy
    Ecophagy is a term coined by Robert Freitas that means the literal consuming of an ecosystem. It derives from the Greek "οικος" or Late Latin "oeco-", which refers to a "house" or "household", and Greek φᾰγεῖν phagein "to eat"...

  • Santa Claus machine
    Santa Claus machine
    A Santa Claus Machine, named after the folkloric Santa Claus, is a hypothetical machine that is capable of creating any required object or structure out of any given material. It is most often referenced by futurists and science fiction writers when discussing hypothetical projects of enormous...



External links

The source of this article is wikipedia, the free encyclopedia.  The text of this article is licensed under the GFDL.
 
x
OK