Molecular epidemiology
Encyclopedia
Molecular epidemiology is a branch of medical science that focuses on the contribution of potential genetic and environmental risk factors, identified at the molecular level, to the etiology
, distribution and prevention of disease within families and across populations. This field has emerged from the integration of molecular biology
into traditional epidemiologic research. Molecular epidemiology
improves our understanding of the pathogenesis
of disease by identifying specific pathways, molecules and gene
s that influence the risk of developing disease.
The phrase "molecular epidemiology" was first coined in 1973 by Kilbourne in an article entitled "The molecular epidemiology of influenza". The term became more formalised with the formulation of the first book on "Molecular Epidemiology: Principles and Practice" by Schulte and Perera. At the heart of this book is the impact of advances in molecular research that have given rise to and enable the measurement and exploitation of the biomarker as a vital tool to link traditional molecular and epidemiological research strategies to understand the underlying mechanisms of disease in populations. Since Kilbourne's use of the term "molecular epidemiology" there has been a steady growth in the use of the term in the scientific articles where over 2500 articles have been published by 2009. In the overall scheme of things, for this time frame, this would not ordinarily be deemed a large number however, yet this does not include the vast explosion of scientific literature on biomarkers, genetics, enzymology as well as molecular and cell biology in relation to disease, all of which lend themselves, but which may not be recognised as, to the concepts and philosophies of molecular epidemiology.
In 1993, around the same time as Schulte and Perera published their book on Molecular Epidemiology there was also the formation of the International Molecular Epidemiology Task Force (IMETAF). This was an ambitious venture, which may have been catalysed by the enthusiasm and expertise drawn together in the preparation of the book but IMETAF does not, despite the meritable objectives, seem to have survived. More than likely its demise was due to its objectives perhaps being ahead of their time in a period of very dynamic change in terms of the molecular and genetic revolution that was underway and researchers' focus being on this and where it would take them. However if anything IMETAF is likely to have been a catalyst to the consideration of Molecular Epidemiology at more manageable National Levels where sustainability would also be more likely. One such example is the formation in 1996 of the Molecular Epidemiological Group (MEG-UK) of the United Kingdom Environmental Mutagen Society (UKEMS). Another example, which also reflects how the field of Cancer Research has probably been the most proactive in embracing the term Molecular Epidemiology in a broadest sense was the formation around the same time of Molecular Epidemiology Group of the American Association of Cancer Research MEG/AACR.,
Etiology
Etiology is the study of causation, or origination. The word is derived from the Greek , aitiologia, "giving a reason for" ....
, distribution and prevention of disease within families and across populations. This field has emerged from the integration of molecular biology
Molecular biology
Molecular biology is the branch of biology that deals with the molecular basis of biological activity. This field overlaps with other areas of biology and chemistry, particularly genetics and biochemistry...
into traditional epidemiologic research. Molecular epidemiology
Epidemiology
Epidemiology is the study of health-event, health-characteristic, or health-determinant patterns in a population. It is the cornerstone method of public health research, and helps inform policy decisions and evidence-based medicine by identifying risk factors for disease and targets for preventive...
improves our understanding of the pathogenesis
Pathogenesis
The pathogenesis of a disease is the mechanism by which the disease is caused. The term can also be used to describe the origin and development of the disease and whether it is acute, chronic or recurrent...
of disease by identifying specific pathways, molecules and gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
s that influence the risk of developing disease.
The phrase "molecular epidemiology" was first coined in 1973 by Kilbourne in an article entitled "The molecular epidemiology of influenza". The term became more formalised with the formulation of the first book on "Molecular Epidemiology: Principles and Practice" by Schulte and Perera. At the heart of this book is the impact of advances in molecular research that have given rise to and enable the measurement and exploitation of the biomarker as a vital tool to link traditional molecular and epidemiological research strategies to understand the underlying mechanisms of disease in populations. Since Kilbourne's use of the term "molecular epidemiology" there has been a steady growth in the use of the term in the scientific articles where over 2500 articles have been published by 2009. In the overall scheme of things, for this time frame, this would not ordinarily be deemed a large number however, yet this does not include the vast explosion of scientific literature on biomarkers, genetics, enzymology as well as molecular and cell biology in relation to disease, all of which lend themselves, but which may not be recognised as, to the concepts and philosophies of molecular epidemiology.
In 1993, around the same time as Schulte and Perera published their book on Molecular Epidemiology there was also the formation of the International Molecular Epidemiology Task Force (IMETAF). This was an ambitious venture, which may have been catalysed by the enthusiasm and expertise drawn together in the preparation of the book but IMETAF does not, despite the meritable objectives, seem to have survived. More than likely its demise was due to its objectives perhaps being ahead of their time in a period of very dynamic change in terms of the molecular and genetic revolution that was underway and researchers' focus being on this and where it would take them. However if anything IMETAF is likely to have been a catalyst to the consideration of Molecular Epidemiology at more manageable National Levels where sustainability would also be more likely. One such example is the formation in 1996 of the Molecular Epidemiological Group (MEG-UK) of the United Kingdom Environmental Mutagen Society (UKEMS). Another example, which also reflects how the field of Cancer Research has probably been the most proactive in embracing the term Molecular Epidemiology in a broadest sense was the formation around the same time of Molecular Epidemiology Group of the American Association of Cancer Research MEG/AACR.,
External links
- MEG/AACR homepage of the Molecular Epidemiology Group of the American Association for Cancer Research
- MEG-UK homepage of the United Kingdom Environmental Mutagen Society (UKMES) Molecular Epidemiology Group
- mEpiWorks homepage of the International Working Group for Molecular Epidemiology (mEpiWorks) - an informal community to support the use of molecular tools in veterinary epidemiology
- Int J Molec Epidemiol Genet homepage of International Journal of Molecular Epidemiology and Genetics
- e-CPC homepage of e-Century Publishing Corporation