Monoiodotyrosine
Encyclopedia
Monoiodotyrosine is a precursor of thyroid hormone
and results from iodization of tyrosine
at the meta-
position of the phenol
ring.
Two units can combine to form 3,3'-diiodothyronine
. One unit can combine with diiodotyrosine
to form triiodothyronine
, as occurs in the colloid of the thyroid follicle.
It is abbreviated "MIT".
Thyroid hormone
The thyroid hormones, thyroxine and triiodothyronine , are tyrosine-based hormones produced by the thyroid gland primarily responsible for regulation of metabolism. An important component in the synthesis of thyroid hormones is iodine. The major form of thyroid hormone in the blood is thyroxine ,...
and results from iodization of tyrosine
Tyrosine
Tyrosine or 4-hydroxyphenylalanine, is one of the 22 amino acids that are used by cells to synthesize proteins. Its codons are UAC and UAU. It is a non-essential amino acid with a polar side group...
at the meta-
Meta- (chemistry)
In chemistry, meta is a prefix, used for systematic names in IUPAC nomenclature. It has several meanings. *In organic chemistry, meta indicates the positions of substituents in aromatic cyclic compounds...
position of the phenol
Phenol
Phenol, also known as carbolic acid, phenic acid, is an organic compound with the chemical formula C6H5OH. It is a white crystalline solid. The molecule consists of a phenyl , bonded to a hydroxyl group. It is produced on a large scale as a precursor to many materials and useful compounds...
ring.
Two units can combine to form 3,3'-diiodothyronine
3,3'-Diiodothyronine
3,3'-Diiodothyronine is a metabolite of thyroid hormone.It is formed from the breakdown of triiodothyronine. It is an allosteric regulator of the Cytochrome C Oxidase, the complex IV of the electron transport chain. It increases its activity by preventing the interaction of ATP as an allosteric...
. One unit can combine with diiodotyrosine
Diiodotyrosine
Diiodotyrosine is a precursor of thyroid hormone and results from iodization of monoiodotyrosine at the other meta- position on the phenol ring....
to form triiodothyronine
Triiodothyronine
Triiodothyronine, C15H12I3NO4, also known as T3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate....
, as occurs in the colloid of the thyroid follicle.
It is abbreviated "MIT".