Morphea profunda
Encyclopedia
Morphea profunda involves deep subcutaneous tissue
, including fascia
, and there is a clinical overlap with eosinophilic fasciitis
, eosinophilia-myalgia syndrome
, and the Spanish toxic oil syndrome
. Morphea profunda shows little response to corticosteroids and tends to run a more chronic debilitating course.
Subcutaneous tissue
The hypodermis, also called the hypoderm, subcutaneous tissue, or superficial fascia is the lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages...
, including fascia
Fascia
A fascia is a layer of fibrous tissue that permeates the human body. A fascia is a connective tissue that surrounds muscles, groups of muscles, blood vessels, and nerves, binding those structures together in much the same manner as plastic wrap can be used to hold the contents of sandwiches...
, and there is a clinical overlap with eosinophilic fasciitis
Eosinophilic fasciitis
Eosinophilic fasciitis , also known as "Shulman's syndrome",is a form of fasciitis. It is distinguished from scleroderma primarily because the affected area is the fascia, not the dermis as in scleroderma...
, eosinophilia-myalgia syndrome
Eosinophilia-myalgia syndrome
Eosinophilia–myalgia syndrome is an incurable and sometimes fatal flu-like neurological condition that is believed to have been caused by ingestion of poorly produced L-tryptophan supplements...
, and the Spanish toxic oil syndrome
Toxic oil syndrome
Toxic Oil Syndrome or simply Toxic Syndrome was the name given to a disease outbreak in Spain in 1981, which killed over 600 people. Its first appearance was as a lung disease, with unusual features: though the symptoms initially resembled a lung infection, antibiotics were ineffective...
. Morphea profunda shows little response to corticosteroids and tends to run a more chronic debilitating course.