Mre11-Rad50-Nbs1
Encyclopedia
The MRN complex is heterotrimeric protein complex
consisting of Mre11
, Rad50
and Nbs1. It is involved in DNA repair
in mammals. Nbs1 is referred to as Nibrin
. This complex recognizes DNA damage and rapidly relocates to DSB sites and forms nuclear foci. Its activity includes end-processing of both physiological and mutagenic DNA double strand breaks (DSBs).. It appears that as part of its end-processing of DSBs, short single-strand oligonucleotides are produced, which induce activation of Ataxia Telangiectasia-Mutated (ATM)
, ultimately leading to activation of the DNA damage checkpoint.
Protein complex
A multiprotein complex is a group of two or more associated polypeptide chains. If the different polypeptide chains contain different protein domain, the resulting multiprotein complex can have multiple catalytic functions...
consisting of Mre11
MRE11A
Double-strand break repair protein MRE11A is a protein that in humans is encoded by the MRE11A gene.-Interactions:MRE11A has been shown to interact with Ku70, Ataxia telangiectasia mutated, MDC1, Rad50, Nibrin, TERF2 and BRCA1.-Further reading:...
, Rad50
RAD50
Rad50 may refer to:* RADIX-50, a character encoding scheme in computing* RAD50 , in biology, encodes a DNA repair protein involved in DNA double-strand break repair...
and Nbs1. It is involved in DNA repair
DNA repair
DNA repair refers to a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as UV light and radiation can cause DNA damage, resulting in as many as 1...
in mammals. Nbs1 is referred to as Nibrin
Nibrin
Nibrin, also known as NBN, is a protein which in humans is encoded by the NBN gene.- Function :Nibrin is a protein associated with the repair of double strand breaks which pose serious damage to a genome. It is a 754 amino acid protein identified as a member of the NBS1/hMre11/RAD50 double strand...
. This complex recognizes DNA damage and rapidly relocates to DSB sites and forms nuclear foci. Its activity includes end-processing of both physiological and mutagenic DNA double strand breaks (DSBs).. It appears that as part of its end-processing of DSBs, short single-strand oligonucleotides are produced, which induce activation of Ataxia Telangiectasia-Mutated (ATM)
Ataxia telangiectasia mutated
Ataxia telangiectasia mutated is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks. It phosphorylates several key proteins that initiate activation of the DNA damage checkpoint, leading to cell cycle arrest, DNA repair or apoptosis...
, ultimately leading to activation of the DNA damage checkpoint.