Muconate lactonizing enzyme
Encyclopedia
Muconate lactonizing enzymes (MLEs) are involved in the breakdown of lignin
-derived aromatics, catechol and protocatechuate, to citric acid cycle
intermediates as a part of the β-ketoadipate pathway in soil microbes. Some bacterial species are also capable of dehalogenating chloroaromatic compounds by the action of chloromuconate lactonizing enzymes. The bacterial MLEs belong to the enolase superfamily
, several structures from which are known.
Lignin
Lignin or lignen is a complex chemical compound most commonly derived from wood, and an integral part of the secondary cell walls of plants and some algae. The term was introduced in 1819 by de Candolle and is derived from the Latin word lignum, meaning wood...
-derived aromatics, catechol and protocatechuate, to citric acid cycle
Citric acid cycle
The citric acid cycle — also known as the tricarboxylic acid cycle , the Krebs cycle, or the Szent-Györgyi-Krebs cycle — is a series of chemical reactions which is used by all aerobic living organisms to generate energy through the oxidization of acetate derived from carbohydrates, fats and...
intermediates as a part of the β-ketoadipate pathway in soil microbes. Some bacterial species are also capable of dehalogenating chloroaromatic compounds by the action of chloromuconate lactonizing enzymes. The bacterial MLEs belong to the enolase superfamily
Enolase superfamily
The reactions catalyzed by enzymes in the enolase superfamily share the core chemical step of an abstraction of a proton from a carbon adjacent to a carboxylic acid and a requirement of a divalent metal ion...
, several structures from which are known.