Murray High School enrolls students in grades nine through twelve. Because of its small enrollment, the school is able to individualize instruction in a way not possible in larger schools.

Murray High School is organized by department, and school days are structured into six periods. In each department there may be integrated, accelerated, and advanced placement classes. The school has a diverse curriculum, which is evident in the extensive list of electives. There are a variety of extracurricular activities, and participation is encouraged.

Students are required to earn a minimum of 22 credits for graduation. These must include four credits of English, three credits of mathematics (including algebra and geometry), three credits of science, three credits of history, one credit of physical education, and one credit of visual/performing arts. Students can elect to earn the Kentucky Commonwealth Diploma, which is a more comprehensive diploma as it requires the student to take four classes for college credit (AP classes).