Myogenin, also known as MYOG, is a gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

.

Myogenin is a muscle-specific basic-helix-loop-helix (bHLH) transcription factor involved in the coordination of skeletal muscle

Skeletal muscle

Skeletal muscle is a form of striated muscle tissue existing under control of the somatic nervous system- i.e. it is voluntarily controlled. It is one of three major muscle types, the others being cardiac and smooth muscle...

 development and repair. Myogenin is a member of the MyoD family of transcription factors

Myogenic regulatory factors

Myogenic regulatory factors are basic-helix-loop-helix transcription factors that regulate myogenesis: MyoD, Myf5, myogenin, and MRF4.These proteins contain a conserved basic DNA binding domain that binds the E box DNA motif . They dimerize with other HLH containing proteins through an HLH-HLH...

, which also includes MyoD

MyoD

MyoD is a protein with a key role in regulating muscle differentiation. MyoD belongs to a family of proteins known as myogenic regulatory factors . These bHLH transcription factors act sequentially in myogenic differentiation. MRF family members include MyoD, Myf5, myogenin, and MRF4 .MyoD is one...

, Myf5

Myf5

Myf5 is a protein with a key role in regulating muscle differentiation.Myf5 belongs to a family of proteins known as myogenic regulatory factors . These bHLH transcription factors act sequentially in myogenic differentiation. MRF family members include Myf5, MyoD , myogenin, and MRF4 ....

, and Mrf4.

In mice, myogenin is essential for the development of functional skeletal muscle. When the DNA coding for myogenin was knocked out of the mouse genome

Genome

In modern molecular biology and genetics, the genome is the entirety of an organism's hereditary information. It is encoded either in DNA or, for many types of virus, in RNA. The genome includes both the genes and the non-coding sequences of the DNA/RNA....

, severe skeletal muscle defects were observed. Mice lacking both copies of myogenin (homozygous-null) suffer from perinatal lethality due to the lack of mature secondary skeletal muscle fibers throughout the body.

In cell culture, myogenin can induce myogenesis in a variety of non-muscle cell types.

Interactions

Myogenin has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with POLR2C

POLR2C

DNA-directed RNA polymerase II subunit RPB3 is an enzyme that in humans is encoded by the POLR2C gene.-Interactions:POLR2C has been shown to interact with TAF15, POLR2F, POLR2G, POLR2H, POLR2J, POLR2K, POLR2L, ATF4, CCHCR1, POLR2A, POLR2B, POLR2E and Myogenin.-Further reading:...

, Sp1 transcription factor, TCF3

TCF3

Transcription factor 3 , also known as TCF3, is a protein that in humans is encoded by the TCF3 gene...

, Serum response factor

Serum response factor

Serum response factor , also known as SRF, is a transcription factor.It is a member of the MADS box superfamily of transcription factors. This protein binds to the serum response element in the promoter region of target genes...

 and MDFI

MDFI

MyoD family inhibitor is a protein that in humans is encoded by the MDFI gene.-Interactions:MDFI has been shown to interact with C9orf86, MyoD, SIX1, Myogenin and GNAI2.-Further reading:...

.

External links