NEFL
Encyclopedia
Neurofilament light polypeptide is a protein
that in humans is encoded by the NEFL gene
.
It is associated with Charcot–Marie–Tooth disease 1F and 2E.
with MAP2
, Protein kinase N1
and TSC1
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the NEFL gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
It is associated with Charcot–Marie–Tooth disease 1F and 2E.
Interactions
NEFL has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with MAP2
MAP2
Microtubule-associated protein 2 is a protein that in humans is encoded by the MAP2 gene.-Interactions:MAP2 has been shown to interact with Grb2, NEFL and MYO7A.. MAP2 is suspected of interacting with tubulin.-Further reading:...
, Protein kinase N1
Protein kinase N1
Serine/threonine-protein kinase N1 is an enzyme that in humans is encoded by the PKN1 gene.-Interactions:Protein kinase N1 has been shown to interact with Phospholipase D1, Phosphoinositide-dependent kinase-1, Vimentin, AKAP9, CCDC85B, Actinin, alpha 1, NEFL, NEUROD2 and RHOA.-Further reading:...
and TSC1
TSC1
Tuberous sclerosis protein 1, also known as TSC1 or hamartin, is a human protein and gene.- Function :This peripheral membrane protein was implicated as a tumor suppressor...
.