Notch homolog 1, translocation-associated (Drosophila), also known as NOTCH1, is a human gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

 encoding a single-pass transmembrane receptor

Receptor (biochemistry)

In biochemistry, a receptor is a molecule found on the surface of a cell, which receives specific chemical signals from neighbouring cells or the wider environment within an organism...

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A deficiency can be associated with bicuspid aortic valve

Bicuspid aortic valve

A bicuspid aortic valve is most commonly a congenital condition of the aortic valve where two of the aortic valvular leaflets fuse during development resulting in a valve that is bicuspid instead of the normal tricuspid configuration. Normally the only cardiac valve that is bicuspid is the mitral...

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There is evidence that activated Notch 1 and Notch 3

Notch 3

Neurogenic locus notch homolog protein 3 is a protein that in humans is encoded by the NOTCH3 gene.-External links:...

 promote differentiation of progenitor cells into astroglia. Interestingliy, Notch 1, then activated before birth, induces radial glia

Radial glia

Radial glial cells are a pivotal cell type in the developing central nervous system involved in key developmental processes, from patterning and neuronal migration to their recently discovered role as precursors during neurogenesis. They arise early in development from neuroepithelial cells...

 differentiation, but postnatally induces the differentiation into astrocyte

Astrocyte

Astrocytes , also known collectively as astroglia, are characteristic star-shaped glial cells in the brain and spinal cord...

s. One study shows that Notch-1 cascade is activated by Reelin

Reelin

Reelin is a large secreted extracellular matrix protein that helps regulate processes of neuronal migration and positioning in the developing brain by controlling cell–cell interactions. Besides this important role in early development, reelin continues to work in the adult brain. It modulates the...

 in an unidentified way. Reelin and Notch1 cooperate in the development of the dentate gyrus

Dentate gyrus

The dentate gyrus is part of the hippocampal formation. It is thought to contribute to new memories as well as other functional roles. It is notable as being one of a select few brain structures currently known to have high rates of neurogenesis in adult rats, .The dentate gyrus cells receive...

, according to another.

Interactions

NOTCH1 has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with MAML1

MAML1

Mastermind-like protein 1 is a protein that in humans is encoded by the MAML1 gene.Details on the activity of the N-terminal domain of Mastermind-like protein 1may be found under MamL-1.-Interactions:...

, GSK3B

GSK3B

Glycogen synthase kinase 3 beta, also known as GSK3B, is an enzyme that in humans is encoded by the GSK3B gene.- Function :Glycogen synthase kinase-3 is a proline-directed serine-threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase. Two isoforms,...

, SNW1

SNW1

SNW domain-containing protein 1 is a protein that in humans is encoded by the SNW1 gene.-Interactions:SNW1 has been shown to interact with Histone deacetylase 2, SKI protein, Retinoblastoma protein, PABPN1, CIR, RBPJ, Nuclear receptor coactivator 1, Nuclear receptor co-repressor 2, Calcitriol...

, Lck

Lck

Lck is a protein that is found inside specialized cells of the immune system called lymphocytes. Lck is a tyrosine kinase, which phosphorylates tyrosine residues of certain proteins involved in the intracellular signaling pathways of these lymphocytes...

, NFKB1

NFKB1

Nuclear factor NF-kappa-B p105 subunit is a protein that in humans is encoded by the NFKB1 gene.This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and...

, RBPJ

RBPJ

Recombining binding protein suppressor of hairless is a protein that in humans is encoded by the RBPJ gene.RBPJ, also named as CBF1, is a human homolog for the Drosophila gene Suppressor of Hairless...

, YY1

YY1

Transcriptional repressor protein YY1 is a protein that in humans is encoded by the YY1 gene.-Interactions:YY1 has been shown to interact with Histone deacetylase 2, FKBP3, ATF6, Myc, SAP30, EP300, HDAC3, NOTCH1 and RYBP....

, NOV

NOV (gene)

Protein NOV homolog is a protein that in humans is encoded by the NOV gene.-Interactions:NOV has been shown to interact with FBLN1 and NOTCH1.-Further reading:...

, Mothers against decapentaplegic homolog 3

Mothers against decapentaplegic homolog 3

Mothers against decapentaplegic homolog 3 also known as SMAD family member 3 or SMAD3 is a protein that in humans is encoded by the SMAD3 gene. SMAD3 is a member of the SMAD family of proteins.The human SMAD3 gene is located on chromosome 15...

 and Ubiquitin C

Ubiquitin C

Ubiquitin is a protein that in humans is encoded by the UBC gene.-Interactions:Ubiquitin C has been shown to interact with SCNN1A, SCNN1G, Parkin , P70-S6 Kinase 1, TRAF6, HDAC3, SFPQ, S100A10, Mothers against decapentaplegic homolog 3, NOTCH1, HIF1A, Epidermal growth factor receptor, E2F1,...

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Further reading

External links