NPR1
Encyclopedia
Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), also known as NPR1, is an atrial natriuretic peptide receptor
. In humans it is encoded by the NPR1 gene
.
that serves as the receptor for both atrial and brain natriuretic peptides (ANP
and BNP
, respectively).
It is localized in the kidney where it results in natriuresis
upon binding to natriuretic peptides. However, it is found in even greater quantity in the lungs and adipocytes.
Atrial natriuretic peptide receptor
A atrial natriuretic peptide receptor is a receptor for atrial natriuretic peptide.- Mechanism :NPRA and NPRB are linked to guanylyl cyclases, while NPRAC is G-protein-linked and is a "clearance receptor" that acts to internalise and destroy the ligand....
. In humans it is encoded by the NPR1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Function
NPR1 is a membrane-bound guanylate cyclaseGuanylate cyclase
-Reaction:Guanylate cyclase catalyzes the reaction of guanosine triphosphate to 3',5'-cyclic guanosine monophosphate and pyrophosphate:-Types:...
that serves as the receptor for both atrial and brain natriuretic peptides (ANP
Atrial natriuretic peptide
Atrial natriuretic peptide , atrial natriuretic factor , atrial natriuretic hormone , or atriopeptin, is a powerful vasodilator, and a protein hormone secreted by heart muscle cells. It is involved in the homeostatic control of body water, sodium, potassium and fat...
and BNP
Brain natriuretic peptide
Brain natriuretic peptide , now known as B-type natriuretic peptide or GC-B, is a 32 amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells...
, respectively).
It is localized in the kidney where it results in natriuresis
Natriuresis
Natriuresis is the process of excretion of sodium in the urine via action of the kidneys. Natriuresis is promoted by Brain and Atrial natriuretic peptides, and it is inhibited by chemicals such as aldosterone...
upon binding to natriuretic peptides. However, it is found in even greater quantity in the lungs and adipocytes.