Negative selection
Encyclopedia
Negative selection may refer to:
- In biology:
- Negative selection (natural selection)Negative selection (natural selection)In natural selection, negative selection or purifying selection is the selective removal of alleles that are deleterious. This can result in stabilizing selection through the purging of deleterious variations that arise....
, in natural selection it refers to the selective removal of rare alleles that are deleterious - Negative selection (artificial selection)Negative selection (artificial selection)In artificial selection, negative selection is where negative, rather than positive, traits of a species are selected for evolutionary continuance...
, in artificial selection it refers to where negative, rather than positive, traits of a species are selected for
- Negative selection (natural selection)
- In politics:
- Negative selection (politics)Negative selection (politics)Negative selection is a political process that occurs especially in rigid hierarchies, most notably dictatorships, but also to lesser degrees in such settings as corporations or electoral politics....
, is a process that occurs in rigid hierarchies, most notably dictatorships
- Negative selection (politics)
- In immunology:
- Negative selection (immunology) T-cells that recognize self MHC molecules (and peptides) with high affinity are deleted from the repertoire of cells. Central toleranceCentral toleranceCentral tolerance is the mechanism by which newly developing T cells and B cells are rendered non-reactive to self. The concept of central tolerance was proposed in 1959 by Joshua Lederberg, as part of his general theory of immunity and tolerance, and is often mistakenly attributed to MacFarlane...
is produced. Avoids auto-immunity. Occurs after positive selection.
- Negative selection (immunology) T-cells that recognize self MHC molecules (and peptides) with high affinity are deleted from the repertoire of cells. Central tolerance