Neonatal lupus erythematosus
Encyclopedia
Neonatal lupus erythematosus is the occurrence of SLE symptoms in an infant
born from a mother with SLE, most commonly presenting with a rash resembling discoid lupus erythematosus
, and sometimes with systemic abnormalities such as heart block
or hepatosplenomegaly
.
The infants have no skin lesions at birth, but develop them during the first weeks of life. Neonatal lupus is usually benign and self-limited.
It is associated with mothers who carry the Ro/SSA antibody.
Infant
A newborn or baby is the very young offspring of a human or other mammal. A newborn is an infant who is within hours, days, or up to a few weeks from birth. In medical contexts, newborn or neonate refers to an infant in the first 28 days after birth...
born from a mother with SLE, most commonly presenting with a rash resembling discoid lupus erythematosus
Discoid lupus erythematosus
Discoid lupus erythematosus is an uncommon autoimmune disease of the basal cell layer of the skin. It occurs in humans and cats, more frequently occurring in dogs. It does not progress to systemic lupus erythematosus in dogs. SLE can also have skin symptoms, but it appears that the two are...
, and sometimes with systemic abnormalities such as heart block
Heart block
A heart block can be a blockage at any level of the electrical conduction system of the heart .* Blocks that occur within the sinoatrial node are described as SA nodal blocks....
or hepatosplenomegaly
Hepatosplenomegaly
Hepatosplenomegaly is the simultaneous enlargement of both the liver and the spleen . Hepatosplenomegaly can occur as the result of acute viral hepatitis or infectious mononucleosis, or it can be the sign of a serious and life threatening lysosomal storage disease...
.
The infants have no skin lesions at birth, but develop them during the first weeks of life. Neonatal lupus is usually benign and self-limited.
It is associated with mothers who carry the Ro/SSA antibody.