Nesprin
Encyclopedia
The Nesprins are a family of proteins that are found primarily in the outer nuclear membrane. Nesprin-1 and -2 bind to the actin filaments. Nesprin-3 binds to plectin
, which is bound to the intermediate filaments, while nesprin-4 interacts with kinesin-1.
Plectin
Plectin is a giant protein found in nearly all mammalian cells which acts as a link between the three main components of the cytoskeleton: actin microfilaments, microtubules and intermediate filaments. In addition plectin links the cytoskeleton to junctions found in the plasma membrane that...
, which is bound to the intermediate filaments, while nesprin-4 interacts with kinesin-1.