The neuromedin U receptors are two G-protein coupled receptors which bind the neuropeptide hormones neuromedin U

Neuromedin U

Neuromedin U is a neuropeptide found in the brain of humans and other mammals, which has a number of diverse functions including contraction of smooth muscle, regulation of blood pressure, pain perception, appetite, bone growth, and hormone release...

 and neuromedin S

Neuromedin S

Neuromedin S is a 36-amino acid neuropeptide found in the brain of humans and other mammals. It is produced in the suprachiasmatic nucleus of the hypothalamus and is related to neuromedin U...

. There are two subtypes of the neuromedin U receptor, each encoded by a separate gene .

Selective Ligands

Neuromedin U is an agonist at both the NMU₁ and NMU₂ subtypes, while neuromedin S is selective for NMU₂, and is a more potent agonist at this subtype than neuromedin U. Several other peptide and non-peptide ligands are also available for the NMU receptors.

Agonists

Non-selective

• Neuromedin U
  Neuromedin U
  Neuromedin U is a neuropeptide found in the brain of humans and other mammals, which has a number of diverse functions including contraction of smooth muscle, regulation of blood pressure, pain perception, appetite, bone growth, and hormone release...
  
  
• non-peptide NMU modulators

NMU₂ selective

• Neuromedin S
  Neuromedin S
  Neuromedin S is a 36-amino acid neuropeptide found in the brain of humans and other mammals. It is produced in the suprachiasmatic nucleus of the hypothalamus and is related to neuromedin U...