Neuronal Calcium Sensor is a large family of proteins which work as calcium dependent molecular switches and includes members like Frequenin (NCS1), recoverin, GCAP, neurocalcin, visinin etc . All the members carry 4 EF hand

EF hand

The EF hand is a helix-loop-helix structural domain found in a large family of calcium-binding proteins. The EF-hand motif contains a helix-loop-helix topology, much like the spread thumb and forefinger of the human hand, in which the Ca2+ ions are coordinated by ligands within the loop...

 motifs (out of which only 2 or 3 bind calcium) and an N-myristoyl group.

Members of NCS family

• Highly evolutionarily conserved

• NCS1 (Frequenin)
• VILIP-1 (Visinin-like-protein-1)
• HPCAL4
  HPCAL4
  Hippocalcin like 4, also known as HPCAL4, is a human gene.-Further reading:...
  
   (Visinin-like-protein-2)
• HPCAL1
  HPCAL1
  Hippocalcin-like protein 1 is a protein that in humans is encoded by the HPCAL1 gene.-Further reading:...
  
   (Visinin-like-protein-3)
• hippocalcin
  Hippocalcin
  Hippocalcin is a protein that in humans is encoded by the HPCA gene.Hippocalcin is a calcium-binding protein that belongs to the neuronal calcium sensor family of proteins. It is expressed in mammalian brains especially in the hippocampus...
  
  
• neurocalcin
  Neurocalcin
  Neurocalcin is a neuronal calcium-binding protein that belongs to the neuronal calcium sensor family of proteins. It expressed in mammalian brains. It possesses a Ca2+/myristoyl switch...
  
  
• recoverin
  Recoverin
  Recoverin is a 23 kilodalton neuronal calcium-binding protein that is primarily detected in the photoreceptor cells of the eye. It plays a key role in the inhibition of rhodopsin kinase, a molecule which regulates the phosphorylation of rhodopsin...
  
  
• Guanylate cyclase activator
  Guanylate cyclase activator
  A guanylate cyclase activator is one of group of proteins which upregulates guanylate cyclase.It is also known as guanylate cyclase-activating protein, with the abbreviation "GCAP".Mutations can be associated with vision defects....
  
   proteins (GCAPs)
• Potassium Channel interacting proteins (KChIPs 1-4), including:

KCNIP1

KCNIP1

Kv channel-interacting protein 1 also known as KChIP1 is a protein that in humans is encoded by the KCNIP1 gene.- Function :This gene encodes a member of the family of voltage-gated potassium channel-interacting proteins , which belong to the recoverin branch of the EF-hand superfamily...

,
KCNIP2

KCNIP2

Kv channel-interacting protein 2 also known as KChIP2 is a protein that in humans is encoded by the KCNIP2 gene.- Function :This gene encodes a member of the family of voltage-gated potassium channel-interacting proteins , which belong to the recoverin branch of the EF-hand superfamily...

,
Calsenilin

Calsenilin

Calsenilin is a protein that in humans is encoded by the KCNIP3 gene.-Interactions:Calsenilin has been shown to interact with PSEN1 and PSEN2.- External links :*...

 or DREAM/KChIP-3/KCNIP3 (downstream regulatory element antagonist modulator/potassium channel interacting protein),
KCNIP4

KCNIP4

Kv channel-interacting protein 4 is a protein that in humans is encoded by the KCNIP4 gene....

External links

• NCS proteins