Nodaviridae
Encyclopedia
Nodaviridae is a family of RNA viruses.
is constructed of 32 capsomers.
The genome is linear, positive sense, bipartite (composed of two segments - RNA1 and RNA2) single stranded RNA
consisting of 4500 nucleotides with a 5’ terminal methylated cap and a non-polyadenylated 3’ terminal.
RNA1, which is ~3.1 kilobases in length, translates encodes a protein that has multiple functional domains: a mitochondrial targeting domain, a transmembrane domain, an RNA-dependent RNA polymerase (RdRp) domain, a self-interaction domain and an RNA capping domain. In addition, RNA1 encodes a subgenomic RNA3 that translates protein B2, an RNA silencing inhibitor.
RNA2 encodes protein α, a viral capsid protein precursor, which is auto-cleaved into two mature proteins, a 38 kDa β protein and a 5 kDa γ protein, at a conserved Asn
/Ala
site during virus assembly.
Alphanodovirus:
Betanodovirus:
Other members include:
While NoV remains the type species for this group, Flock House Virus (FHV) is the best studied of the Nodaviruses.
Virology
The virus is not enveloped and has an isocahedral capsid (triangulation number = 3) ranging from 29 to 35 nm in diameter. The capsidCapsid
A capsid is the protein shell of a virus. It consists of several oligomeric structural subunits made of protein called protomers. The observable 3-dimensional morphological subunits, which may or may not correspond to individual proteins, are called capsomeres. The capsid encloses the genetic...
is constructed of 32 capsomers.
The genome is linear, positive sense, bipartite (composed of two segments - RNA1 and RNA2) single stranded RNA
RNA
Ribonucleic acid , or RNA, is one of the three major macromolecules that are essential for all known forms of life....
consisting of 4500 nucleotides with a 5’ terminal methylated cap and a non-polyadenylated 3’ terminal.
RNA1, which is ~3.1 kilobases in length, translates encodes a protein that has multiple functional domains: a mitochondrial targeting domain, a transmembrane domain, an RNA-dependent RNA polymerase (RdRp) domain, a self-interaction domain and an RNA capping domain. In addition, RNA1 encodes a subgenomic RNA3 that translates protein B2, an RNA silencing inhibitor.
RNA2 encodes protein α, a viral capsid protein precursor, which is auto-cleaved into two mature proteins, a 38 kDa β protein and a 5 kDa γ protein, at a conserved Asn
Asparagine
Asparagine is one of the 20 most common natural amino acids on Earth. It has carboxamide as the side-chain's functional group. It is not an essential amino acid...
/Ala
Alanine
Alanine is an α-amino acid with the chemical formula CH3CHCOOH. The L-isomer is one of the 20 amino acids encoded by the genetic code. Its codons are GCU, GCC, GCA, and GCG. It is classified as a nonpolar amino acid...
site during virus assembly.
Taxonomy
The members of the alphanodoviridae were origianlly isolated from insects while those of the betanodoviridae were isolated from fish. A small number of nodoviruses seem to lie outside either of these clades.Alphanodovirus:
- Black beetle virus
- Boolarra virus
- Flock House virus
- Nodamura virus
- Macrobrachium rosenbergii nodavirus
- Pariacoto virus
- Penaeus vannamei nodavirus
- Tn-5 drived nodavirus
Betanodovirus:
- Atlantic halibut nodavirus
- Epinephelus tauvina nervous necrosis virus
- Red-spotted grouper nervous necrosis Virus
- Sevenband grouper nervous necrosis virus
- Striped jack nervous necrosis virus
Other members include:
- Gypsy moth virus (GMV)
- Manawatu virus (MwV)
- Wuhan Nodaviru
While NoV remains the type species for this group, Flock House Virus (FHV) is the best studied of the Nodaviruses.