Nodular sclerosis
Encyclopedia
Nodular sclerosis is a form of Hodgkin's lymphoma
that is the most common subtype of HL in developed countries. It affects females and males equally and has a median age of onset at ~28 years. It is composed of large tumor nodules with lacunar Reed-Sternberg cell
(RS cells) surrounded by fibrotic collagen bands.
The British National Lymphoma Investigation further categorized NSHL based upon Reed-Sternberg cells into "nodular sclerosis type I" (NS I) and "nodular sclerosis type II" (NS II), with the first subtype responding better to treatment.
Hodgkin's lymphoma
Hodgkin's lymphoma, previously known as Hodgkin's disease, is a type of lymphoma, which is a cancer originating from white blood cells called lymphocytes...
that is the most common subtype of HL in developed countries. It affects females and males equally and has a median age of onset at ~28 years. It is composed of large tumor nodules with lacunar Reed-Sternberg cell
Reed-Sternberg cell
Reed–Sternberg cells are different giant cells found with light microscopy in biopsies from individuals with Hodgkin's lymphoma primarily due to EBV, and certain other disorders...
(RS cells) surrounded by fibrotic collagen bands.
The British National Lymphoma Investigation further categorized NSHL based upon Reed-Sternberg cells into "nodular sclerosis type I" (NS I) and "nodular sclerosis type II" (NS II), with the first subtype responding better to treatment.
External links
- Illustration, at UMDNJ
- Illustration
- PubMed - use of ErythropoietinErythropoietinErythropoietin, or its alternatives erythropoetin or erthropoyetin or EPO, is a glycoprotein hormone that controls erythropoiesis, or red blood cell production...
- Subtypes
- Lymphoma Association information on nodular sclerosing