Nonsense suppressor
Encyclopedia
A nonsense suppressor is a tRNA mutation
that suppresses the protein truncation resulting from a nonsense mutation
.
The nonsense suppressor is a tRNA gene (from Escherichia coli
) which has a mutated anticodon.
The mutated anticodon recognizes the nonsense stop codon
.
SUP35, a nonsense suppressor identified by Wickner
in 1994, is a prion protein
.
Mutation
In molecular biology and genetics, mutations are changes in a genomic sequence: the DNA sequence of a cell's genome or the DNA or RNA sequence of a virus. They can be defined as sudden and spontaneous changes in the cell. Mutations are caused by radiation, viruses, transposons and mutagenic...
that suppresses the protein truncation resulting from a nonsense mutation
Nonsense mutation
In genetics, a nonsense mutation is a point mutation in a sequence of DNA that results in a premature stop codon, or a nonsense codon in the transcribed mRNA, and in a truncated, incomplete, and usually nonfunctional protein product. It differs from a missense mutation, which is a point mutation...
.
The nonsense suppressor is a tRNA gene (from Escherichia coli
Escherichia coli
Escherichia coli is a Gram-negative, rod-shaped bacterium that is commonly found in the lower intestine of warm-blooded organisms . Most E. coli strains are harmless, but some serotypes can cause serious food poisoning in humans, and are occasionally responsible for product recalls...
) which has a mutated anticodon.
The mutated anticodon recognizes the nonsense stop codon
Genetic code
The genetic code is the set of rules by which information encoded in genetic material is translated into proteins by living cells....
.
SUP35, a nonsense suppressor identified by Wickner
Reed Wickner
Reed B. Wickner is an American yeast geneticist. In 1994 he proposed that the [PSI+] and [URE3] phenotypes in Saccharomyces cerevisiae, a form of budding yeast, were caused by prion forms of native proteins. Specifically, the sup35p protein....
in 1994, is a prion protein
Prion
A prion is an infectious agent composed of protein in a misfolded form. This is in contrast to all other known infectious agents which must contain nucleic acids . The word prion, coined in 1982 by Stanley B. Prusiner, is a portmanteau derived from the words protein and infection...
.